Is Primary Tumor Excision and Specific Metastases Sites Resection Associated With Improved Survival in Stage Ⅳ Colorectal Cancer? Results From SEER Database Analysis

The American Surgeon
Chenghao YiZhen Zong

Abstract

We aimed to explore the prognostic value of primary tumor and specific metastases excision on survival among patients with stage IV colorectal cancer (CRC) in the Surveillance, Epidemiology, and End Results (SEER) database. Patients with stage IV CRC were selected using SEER database between 2010 and 2013. Survival rate was calculated according to the Kaplan-Meier method, and differences between curves were tested by the log-rank test. Cox proportional hazards model was used in the multivariable analysis. Included in this study were 27 878 patients with distant metastatic CRC. Among the single organ site of metastatic CRC, patients with solitary metastasis of lung showed the highest median overall survival (OS). Both primary and metastatic sites surgical resection for patients with liver, lung, and simultaneous liver and lung metastases had better median OS. Age younger than 65 years, Asian and Pacific Islander, distal colon and rectum, and palliative primary tumor and metastatic lesions resection were associated with better OS after multivariate analysis. Palliative primary tumor and metastatic lesions resection had a significant survival benefit compared with nonsurgical group in selected patients. These findings support the ...Continue Reading

References

May 17, 2000·Diseases of the Colon and Rectum·W E LongoS F Khuri
Jun 22, 2001·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H LegendreJ C Pector
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott KopetzRobert R McWilliams
Jul 14, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Hannes NeeffBernward Passlick
Aug 13, 2009·Journal of the National Cancer Institute·Charlie Schmidt
Nov 16, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Gabriela M VargasTaylor S Riall
Nov 16, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Amy CollinsMark Bloomston
Jun 24, 2014·International Journal of Colorectal Disease·Shahid AhmedNayyer Iqbal
Sep 10, 2014·Annals of Surgical Oncology·Nicolas C BuchsChristian Toso
Dec 5, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Andrew J PageTimothy M Pawlik
Feb 11, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neil S HorowitzG Larry Maxwell
Mar 11, 2015·International Journal of Radiation Oncology, Biology, Physics·Aaron SabolchShruti Jolly
Jul 25, 2015·Journal of the National Cancer Institute·Caitlin C MurphyAnn M Geiger
Feb 7, 2016·The Journal of Surgical Research·Lauren M WancataSandra L Wong
Jul 7, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Van CutsemD Arnold
Mar 2, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

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