Is procalcitonin a reliable marker for the diagnosis of infected pancreatic necrosis?

ANZ Journal of Surgery
Nadir YonetciOmer Ozutemiz

Abstract

Infected necrosis in acute pancreatitis is the main factor in determining the prognosis of the disease. Early and accurate diagnosis of infected pancreatic necrosis might decrease mortality. The aim of the present study is to identify a reliable marker for the onset infection in three different experimentally induced pancreatitis models. Ninety female Wistar albino rats were randomly divided into nine groups. In three different experimental models, including cerulein induced acute oedematous pancreatitis (AEP), sterile pancreatic necrosis due to taurocholate-induced acute pancreatitis (SPN) and infected pancreatic necrosis taurocholate-induced acute pancreatitis (IPN). Serum levels of procalcitonin (PCT), C-reactive protein (CRP), tumour necrosis factor a (TNF-alpha), interleukin 6 (IL-6) and interleukin 8 (IL-8), amylase were measured. The degree of pancreatic damage also evaluated pathologically. Procalcitonin levels were increased significantly in AEP, SPN and IPN compared to control groups (P < 0.05). PCT and IL-6 level were the highest in the IPN group (P < 0.05). Serum amylase, CRP, TNF-alpha, IL-2, and IL-8 levels were similar between IPN and SPN groups (P > 0.05), but higher than in other groups. The results of histolog...Continue Reading

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Citations

Sep 17, 2015·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Halil ErbısErgun Erdem
Jun 11, 2014·Scandinavian Journal of Gastroenterology·Mustafa KaplanOsman Metin Ipcioglu
Aug 11, 2015·Journal of Immunology Research·Ildikó LászlóJános Fazakas
May 22, 2020·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Anirban Hom ChoudhuriRajeev Uppal

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