Is prolonged monitoring necessary? An updated approach to infantile hemangioma treatment with oral propranolol.

Pediatric Dermatology
Maija Liv JohansenLeslie P Lawley

Abstract

Infantile hemangiomas (IH) are the most common soft-tissue tumors in childhood, occurring in up to 1 in 10 infants. Oral propranolol has been well established as the first-line treatment of complicated hemangiomas; however, variability in the administration protocol remains. We sought to evaluate our current propranolol treatment protocols to determine if the level of monitoring and follow-up predicts immediate or future adverse events by comparing one in-person visit vs two in-person visits versus teledermatology for treatment initiation and dose escalation. We analyzed retrospective data on 279 patients diagnosed with IH and treated with oral propranolol on an in-person or virtual telemedicine outpatient basis from January 01, 2015 through May 31, 2020. Data were collected via chart review on all aspects of patient demographics, treatment indication, treatment initiation, adverse events, and follow-up visits. Two monitoring visits (Protocol 1) versus one (Protocol 2) was not associated with decreased adverse outcomes (P = .255). The odds of having an adverse event in Protocol 1 compared to Protocol 2 was insignificant (OR: 0.64; CI: 0.30-1.38). The most frequently reported adverse event among patients in both protocols was sl...Continue Reading

References

Jun 14, 2008·The New England Journal of Medicine·Christine Léauté-LabrèzeAlain Taïeb
Oct 15, 2011·Pediatric Dermatology·Christine J SchuppStefan Holland-Cunz
Nov 19, 2013·Archives of Disease in Childhood. Education and Practice Edition·Lauren Biesbroeck, Heather A Brandling-Bennett
Feb 19, 2015·The New England Journal of Medicine·Christine Léauté-LabrèzeJean-Jacques Voisard
Jan 28, 2016·JAMA : the Journal of the American Medical Association·Sorilla PreyKhaled Ezzedine
May 24, 2019·Pediatric Dermatology·Elana PuttermanAlbert C Yan
Apr 17, 2020·Pediatric Dermatology·Ilona J FriedenUNKNOWN Hemangioma Investigator Group

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