Is PSA related to serum cholesterol and does the relationship differ between black and white men?

The Prostate
Daniel ZapataStephen J Freedland

Abstract

Previously, in prostate cancer-free men, we found that statin initiation resulted in a 4.1% decline in PSA. This decline in PSA was proportional to the decline in cholesterol, suggesting a link between cholesterol and PSA levels. Whether these associations vary by race has not been explored and therefore we examined the association between pre-statin serum cholesterol and PSA in black and white prostate cancer-free men. We conducted a retrospective, cross-sectional analysis of 1,163 men (709 white and 454 black) without prostate cancer who initiated a statin between 1994 and 2006. Linear regression was used to test the association between pre-statin serum cholesterol and PSA levels, adjusting for potential confounders and stratifying by race. Black men were younger, had higher low-density lipoprotein (LDL) and high-density lipoprotein (HDL) levels (both P < 0.05) and a trend toward higher total cholesterol (P = 0.063). There was no difference in PSA or year of statin prescription by race (P = 0.900 and P = 0.217, respectively). On multivariable analysis, we found a positive correlation between serum PSA and total cholesterol (P = 0.005) and LDL (P = 0.003) in white men, but no association among black men. HDL was not significan...Continue Reading

References

May 30, 1998·Journal of the National Cancer Institute·J A EasthamO Sartor
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Dec 23, 2003·Journal of Cellular Biochemistry·Michael R Freeman, Keith R Solomon
Nov 19, 2004·European Urology·Igor StancikWolfgang Hoeltl
Apr 20, 2006·Journal of the National Cancer Institute·Ian M ThompsonCharles A Coltman
Oct 30, 2008·Journal of the National Cancer Institute·Robert J HamiltonStephen J Freedland
Nov 20, 2009·The Aging Male : the Official Journal of the International Society for the Study of the Aging Male·Halina GrosmanGabriela Berg
Dec 10, 2009·The Prostate·David J MenerGanesh S Palapattu
Feb 18, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lionel L BañezStephen J Freedland
Jul 8, 2010·Urology·Bulent AkdumanE David Crawford
Aug 4, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven L ChangJoseph C Presti
Jan 5, 2011·Psychoneuroendocrinology·Yori GidronGabriela Berg
Sep 15, 2011·Cancer Causes & Control : CCC·Alison M MondulDemetrius Albanes
Nov 29, 2011·European Urology·Cosimo De NunzioJ Kellogg Parsons
Dec 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·I Hanukoglu
Jan 27, 2012·Journal of Thrombosis and Thrombolysis·April L RodriguezJose A Diaz
Jul 31, 2013·Journal of the American Geriatrics Society·Scott D NashMichael Y Tsai
Feb 13, 2014·European Journal of Epidemiology·Mathilde HisMathilde Touvier
Oct 12, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Emma H AllottStephen J Freedland
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Apr 1, 2013·Journal of Pharmaceutical Analysis·Xin ChenGuang-Bin Zhang

❮ Previous
Next ❯

Citations

Sep 2, 2016·Therapeutic Advances in Medical Oncology·Michael T Schweizer, Evan Y Yu
Dec 29, 2017·Prostate Cancer and Prostatic Diseases·Juzar JamnagerwallaStephen J Freedland
May 31, 2019·International Journal of Molecular Sciences·Gergana E Stoykova, Isabel R Schlaepfer
Dec 20, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Ying ZhaoZongtao Chen
May 1, 2020·American Journal of Men's Health·Hisashi HiranoShigeo Horie
May 26, 2018·Prostate Cancer and Prostatic Diseases·Emma H AllottStephen J Freedland
Mar 17, 2021·Journal of Clinical Laboratory Analysis·Manuel M GarridoJoão T Guimarães
Mar 23, 2021·Translational Oncology·Shyamananda Singh MayengbamManoj Kumar Bhat

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Prostate Cancer and Prostatic Diseases
D E G KokL A L M Kiemeney
International Journal of Urology : Official Journal of the Japanese Urological Association
Daniel F ZapataStephen J Freedland
Arteriosclerosis and Thrombosis : a Journal of Vascular Biology
D S FreedmanJ J Barboriak
Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Fatma Ferda VeritNafi Sakar
© 2021 Meta ULC. All rights reserved