Is pure red cell aplasia a new extra digestive manifestation of celiac disease?

La Revue de médecine interne
A-L CoudercB Granel

Abstract

Celiac disease is an autoimmune enteropathy that appears on a predisposed genetic background. Its clinical presentation has been extended those last years by varied extradigestive manifestations. This is a case report of a twenty-year-old woman who presented simultaneously a celiac disease and pure red cell aplasia. The IgA and IgG antigliadin antibodies as well as antinuclear, anti-DNA, anti-SSA and anti-SSB antibodies were detected, without any clinical symptom supporting the diagnosis of systemic lupus erythematosus or Sjögren syndrome. Thoracic CT-scan reveals a thymus enlargement and biopsy concludes to thymus hyperplasia at histological examination. Pure red cell aplasia regressed after gluten-free diet, corticoid therapy and thymectomy. This observation, added to the three others paediatric cases previously published in the literature concern an uncommon association between pure red cell aplasia and celiac disease. However, they are not enough to conclude to a direct link between these two disorders. Pure red cell aplasia could represent un new dysimmune manifestation occurring in celiac disease, but this will need to be confirmed with others cases.

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Citations

Nov 30, 2013·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·L Alonso CanalM J Martínez Gómez
Jun 1, 2011·European Neurology·Marzanna Wiechetek OstosArmin von Gunten
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