Is pyrazinamide bactericidal against Mycobacterium tuberculosis?

The American Review of Respiratory Disease
L B Heifets, P J Lindholm-Levy

Abstract

Bactericidal activity of pyrazinamide (PZA) was tested at pH 5.6 in 7H12 broth against drug-susceptible M. tuberculosis strains. The highest tested concentrations of PZA, 500 and 1,000 micrograms/ml, killed no more than 76% of the bacterial population. These concentrations are more than 32 times greater than the minimal inhibitory concentration (MIC) and the achievable in vivo concentrations. Despite high clinical efficacy of PZA and its so-called sterilizing activity in mouse experiments, this drug is much less bactericidal in vitro than any other known antituberculosis drug.

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Citations

Aug 1, 1994·International Journal of Antimicrobial Agents·V St Georgiev
Oct 25, 2011·The Journal of Infectious Diseases·Shashikant SrivastavaTawanda Gumbo
Dec 1, 1992·The American Review of Respiratory Disease·J A SbarbaroA J Crowle
Jan 1, 1991·Journal of Toxicology. Clinical Toxicology·C H Hobbs, J L Mauderly
Nov 2, 2015·Advances in Medical Sciences·Moses NjireTianyu Zhang
Mar 18, 2006·American Journal of Respiratory Cell and Molecular Biology·Michael P PietilaCharles F Thomas
Jun 25, 2015·Microbiology Spectrum·Ying ZhangDenis Mitchison

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