Is radiation indicated in patients with ductal carcinoma in situ and close or positive mastectomy margins?

International Journal of Radiation Oncology, Biology, Physics
Linda W ChanBarbara Fowble

Abstract

Resection margin status is one of the most significant factors for local recurrence in patients with ductal carcinoma in situ (DCIS) treated with breast-conserving surgery with or without radiation. However, its impact on chest wall recurrence in patients treated with mastectomy is unknown. The purpose of this study was to determine chest wall recurrence rates in women with DCIS and close (<5 mm) or positive mastectomy margins in order to evaluate the potential role of radiation therapy. Between 1985 and 2005, 193 women underwent mastectomy for DCIS. Fifty-five patients had a close final margin, and 4 patients had a positive final margin. Axillary surgery was performed in 17 patients. Median follow-up was 8 years. Formal pathology review was conducted to measure and verify margin status. Nuclear grade, architectural pattern, and presence or absence of necrosis was recorded. Median pathologic size of the DCIS in the mastectomy specimen was 4.5 cm. Twenty-two patients had DCIS of >5 cm or diffuse disease. Median width of the close final margin was 2 mm. Nineteen patients had margins of <1 mm. One of these 59 patients experienced a chest wall recurrence with regional adenopathy, followed by distant metastases 2 years following ski...Continue Reading

References

Feb 1, 1977·Cancer·R AshikariR E Snyder
Jan 1, 1989·Archives of Surgery·D W KinneP P Rosen
Feb 15, 1989·Cancer·A S PatchefskyS A Feig
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M J SilversteinP Gamagami
Sep 1, 1996·Plastic and Reconstructive Surgery·G W CarlsonT M Styblo
Feb 1, 2003·Plastic and Reconstructive Surgery·Aldona J Spiegel, Charles E Butler
Jul 14, 2006·Breast Cancer Research and Treatment·Eileen RakovitchLawrence Paszat
May 8, 2007·Journal of the American College of Surgeons·Grant W CarlsonWilliam C Wood
Jun 21, 2007·American Journal of Clinical Pathology·Edwin R FisherNorman Wolmark
Feb 6, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lars HolmbergStefan Emdin
Oct 29, 2008·International Journal of Radiation Oncology, Biology, Physics·Afshin RashtianSathima Natarajan

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Citations

Mar 10, 2016·Clinical Breast Cancer·Talha ShaikhPenny Anderson
Dec 1, 2012·International Journal of Radiation Oncology, Biology, Physics·Dawn OwenElaine S Wai
Mar 26, 2014·The British Journal of Surgery·S A RobertsonR I Cutress
Jul 11, 2012·International Journal of Surgical Oncology·Manjeet ChadhaLouis B Harrison
Sep 1, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·K ClementsUNKNOWN Sloane Project Steering Group
May 1, 2012·International Journal of Radiation Oncology, Biology, Physics·Stephanie K ChildsJennifer R Bellon
Feb 6, 2020·Critical Reviews in Oncology/hematology·Angel MonteroCarmen Rubio
Jun 18, 2021·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Trine TrammOrit Kaidar-Person

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Ductal carcinoma is a malignant neoplasm involving the ductal systems of any of a number of organs, such as the mammary glands, pancreas, prostate or lacrimal gland. Discover the latest research on ductal carcinoma here.

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