Is radiofrequency ablation more effective than stereotactic ablative radiotherapy in patients with early stage medically inoperable non-small cell lung cancer?

Interactive Cardiovascular and Thoracic Surgery
Haris BilalRajesh Shah

Abstract

A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was 'is radiofrequency ablation more effective than stereotactic ablative radiotherapy in patients with early stage medically inoperable non-small cell lung cancer?' Altogether, over 219 papers were found, of which 16 represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Radiofrequency ablation (RFA) and stereotactic ablative radiotherapy (SABR) offer a clear survival benefit compared with conventional radiotherapy in the treatment of early stage non-small cell lung cancer (NSCLC) in medically inoperable patients. Overall survival at 1 year (68.2-95% vs. 81-85.7%) and 3 years (36-87.5% vs. 42.7-56%) was similar between patients treated with RFA and SABR. However, 5-year survival was higher in SABR (47%) than RFA (20.1-27%). Local progression rates were lower in patients treated with SABR (3.5-14.5% vs. 23.7-43%). Both treatments were associated with complications. Pneumothorax (19.1-63%) was the most common complication following RFA. Fatigue (31-32.6%), pneum...Continue Reading

References

Oct 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert TimmermanJames Fletcher
Mar 30, 2007·Radiology·Caroline J SimonWilliam W Mayo-Smith
Apr 6, 2007·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Quynh-Thu LeJessica Donington
Aug 3, 2007·Interactive Cardiovascular and Thoracic Surgery·Joel DunningKevin Mackway-Jones
Oct 2, 2007·The Journal of Thoracic and Cardiovascular Surgery·Arjun PennathurRodney J Landreneau
Nov 3, 2007·The Journal of Thoracic and Cardiovascular Surgery·Takao HirakiSusumu Kanazawa
Jan 1, 2008·International Journal of Radiation Oncology, Biology, Physics·Frank J LagerwaardS Senan
Mar 3, 2009·International Journal of Radiation Oncology, Biology, Physics·Achilles J FakirisRobert Timmerman
Jun 24, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Max DaheleAndrea Bezjak
Sep 8, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Janneke P C GruttersPhilippe Lambin
Mar 18, 2010·JAMA : the Journal of the American Medical Association·Robert TimmermanHak Choy
Jul 9, 2010·Journal of the American College of Surgeons·Alla ZemlyakThomas V Bilfinger
Jul 29, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Lijun HuangKunxiang Gao
Sep 24, 2011·AJR. American Journal of Roentgenology·Masataka KashimaAtsuhiro Nakatsuka

❮ Previous
Next ❯

Citations

Oct 18, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Vaclav SimanekHynek Mirka
Apr 16, 2016·The Indian Journal of Radiology & Imaging·Shivank BhatiaNiramol Savaraj
Jun 2, 2015·Clinical Lung Cancer·Guy C JonesAradhana Kaushal
Sep 27, 2014·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Guanghui HuangAimin Zheng
Mar 15, 2015·Radiología·J M Plasencia Martínez
Feb 13, 2014·Oral Oncology·Oscar S H Chan, Roger K C Ngan
Jun 14, 2016·Chest·Kassem HarrisDaniel Sterman
Jun 29, 2017·AJR. American Journal of Roentgenology·Samdeep K MouliRobert J Lewandowski
Dec 3, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David A PalmaGeorge B Rodrigues
Apr 4, 2021·Journal of Vascular and Interventional Radiology : JVIR·Johannes UhligHyun S Kim
Sep 1, 2013·EJC Supplements : EJC : Official Journal of EORTC, European Organization for Research and Treatment of Cancer ... [et Al.]·Jan P van Meerbeeck

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Eva E SchaakeHouke M Klomp
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
David Ball
Annals of Oncology : Official Journal of the European Society for Medical Oncology
L CrinòESMO Guidelines Working Group
© 2021 Meta ULC. All rights reserved