PMID: 8942335Oct 1, 1996Paper

Is recovery of neuromuscular transmission complete after the use of neostigmine to antagonize block produced by rocuronium, vecuronium, atracurium and pancuronium?

British Journal of Anaesthesia
M J BaurainF R Cantraine

Abstract

To test if recovery of neuromuscular transmission is complete after the use of neostigmine under standardized conditions, we have measured adductor pollicis mechanical activity in response to 0.1 Hz (twitch height), train-of-four (TOF) and 100 Hz (RF 100 Hz) ulnar nerve stimulations. We studied 56 adult anaesthetized (thiopentone, fentanyl, nitrous oxide in oxygen) patients, allocated randomly to one of four groups (n = 14) to receive rocuronium (group Roc), vecuronium (group Vec), atracurium (group Atr) or pancuronium (group Pan). Recovery of neuromuscular transmission was studied for 15 min after neostigmine 40 micrograms kg-1 was given at 25% recovery of twitch height. Fifteen minutes after antagonism, the TOF ratio was 0.91 (SEM 0.01), 0.88 (0.02) and 0.92 (0.01) (ns), and RF 100 Hz was 0.78 (0.01), 0.79 (0.02) and 0.78 (0.01) (ns) respectively, in patients in groups Roc, Vec and Atr, respectively. In patients in group Pan, TOF ratio and RF 100 Hz were only 0.76 (0.01) and 0.33 (0.04) respectively (P < 0.01, one-way analysis of variance, Duncan's multiple classification range tests). In contrast with pancuronium, antagonism of rocuronium-, vecuronium- and atracurium-induced neuromuscular blocks produced a similar high degre...Continue Reading

Citations

Jul 9, 2010·Fukushima Journal of Medical Science·Yuhji SaitohMasahiro Murakawa
Oct 27, 2009·Annales Françaises D'anesthèsie Et De Rèanimation·A-A d'Hollander, J-L Bourgain
Jul 26, 2005·Annales Françaises D'anesthèsie Et De Rèanimation·M Beaussier, M A Boughaba
Jun 4, 2016·Veterinary Anaesthesia and Analgesia·Manuel Martin-FloresGabriela E Aguirre
Sep 30, 2005·Anesthesiology·Francois GijsenberghThijs van Iersel
May 28, 2005·Anesthesia and Analgesia·Glenn S MurphyJeffery S Vender
Jul 28, 1999·Anesthesiology·R PurdyJ L Lichtor
Oct 24, 2012·Anesthesiology·Gopalaiah Venkatesh KumarGundappa Parameshwara
May 16, 2000·Anesthesia and Analgesia·David R Bevan

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