PMID: 11918085Mar 29, 2002Paper

Is reduced expression of mismatch repair genes MLH1 and MSH2 in patients with sporadic colorectal cancer related to their prognosis?

Clinical & Experimental Metastasis
Martin KruschewskiHeinz Johannes Buhr

Abstract

The majority of mutations in hereditary nonpolyposis colon carcinoma (HNPCC) patients affect the mismatch-repair genes (MMRG) MLHI and MSH2. In addition, mutations of these genes were found in about 15% of sporadic colorectal carcinomas which appear to be related to microsatellite instability (MSI). However, mutations in MMRG were not found in all MSI-positive carcinomas, but MMRG mutations may be relevant for the assessment of tumor characteristics and patients' prognosis. Therefore, we investigated the relationship between expression of MMRG, tumor biology and patients' survival. In 127 patients with sporadic colorectal carcinomas and a minimum of 5 years follow-up after curative surgery immunohistochemical detection of MLHI and MSH2 was analyzed semiquantitatively. Lost expression of MLHI has been found in tumor specimens from 10 patients, whereas MSH2 expression was missing in 5 patients. This reduced expression did not correlate with tumor stage, lymph node involvement, grading or tumor invasion into blood vessels. However, a significant correlation was found for lymphovascular invasion (P = 0.02) and localization within the colorectum (P = 0.003) in MLH1-negative carcinomas. In addition, although there was a clear tendenc...Continue Reading

Citations

Oct 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gershon Y LockerUNKNOWN ASCO
May 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giovanni LanzaLuigi Cavazzini
Oct 25, 2003·The American Journal of Surgical Pathology·Cheryl L Wright, Ian D Stewart
Nov 12, 2013·Journal of Applied Oral Science : Revista FOB·Camila Santos PereiraAlfredo Maurício Batista De Paula
May 30, 2013·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Wen-Jing LiuHong Shu
Sep 24, 2004·The British Journal of Surgery·S AnwarG L Carlson

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