PMID: 3773199Nov 28, 1986Paper

Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT)

JAMA : the Journal of the American Medical Association
J StamlerJ D Neaton

Abstract

The 356,222 men aged 35 to 57 years, who were free of a history of hospitalization for myocardial infarction, screened by the Multiple Risk Factor Intervention Trial (MRFIT) in its recruitment effort, constitute the largest cohort with standardized serum cholesterol measurements and long-term mortality follow-up. For each five-year age group, the relationship between serum cholesterol and coronary heart disease (CHD) death rate was continuous, graded, and strong. For the entire group aged 35 to 57 years at entry, the age-adjusted risks of CHD death in cholesterol quintiles 2 through 5 (182 to 202, 203 to 220, 221 to 244, and greater than or equal to 245 mg/dL [4.71 to 5.22, 5.25 to 5.69, 5.72 to 6.31, and greater than or equal to 6.34 mmol/L]) relative to the lowest quintile were 1.29, 1.73, 2.21, and 3.42. Of all CHD deaths, 46% were estimated to be excess deaths attributable to serum cholesterol levels 180 mg/dL or greater (greater than or equal to 4.65 mmol/L), with almost half the excess deaths in serum cholesterol quintiles 2 through 4. The pattern of a continuous, graded, strong relationship between serum cholesterol and six-year age-adjusted CHD death rate prevailed for nonhypertensive nonsmokers, nonhypertensive smokers...Continue Reading

Citations

Oct 23, 2004·Science·Frederick H WilsonRichard P Lifton
Jan 16, 2014·Current Atherosclerosis Reports·Stephen J Nicholls, Yu Kataoka
Jan 29, 2014·Herz·F Custodis, U Laufs
Oct 7, 1995·Lancet·R M Norris
Jan 5, 2012·Clinical Lipidology·Carlos D Malvestutto, Judith A Aberg
Dec 10, 2013·La Revue de médecine interne·D Vital Durand
May 24, 2006·Bioscience, Biotechnology, and Biochemistry·Hiroko InoueToshichika Takita
May 8, 2009·Current Gerontology and Geriatrics Research·Göran NilssonPär Hedberg
Apr 6, 2012·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·I van DisD Kromhout
Jun 17, 2014·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Nuria PlanaLluis Masana
Sep 30, 2014·Reviews in Endocrine & Metabolic Disorders·Mitsuyoshi Takahara, Iichiro Shimomura
Apr 29, 2010·Current Rheumatology Reports·Ankoor Shah, Robert T Keenan
Jan 12, 2001·Japanese Circulation Journal·T NakamuraUNKNOWN Group of the Research for the Association between Host Origin and Atherosclerotic Diseases under the Preventive Measure for
Dec 1, 1989·Controlled Clinical Trials·U Gundert-Remy
Jun 12, 2010·Nutrition Reviews·Amy M Brownawell, Michael C Falk
Dec 1, 1990·Baillière's Clinical Endocrinology and Metabolism·W Krone, D Müller-Wieland
Apr 9, 2008·Journal of Atherosclerosis and Thrombosis·Roderick F G J KingPaul J Gately
Dec 25, 2009·Journal of Atherosclerosis and Thrombosis·Hiroki SatohHiroyuki Tsutsui
Jun 27, 2009·Journal of Atherosclerosis and Thrombosis·Tomoaki SaekiGenjiro Kimura
Aug 13, 2009·Journal of Atherosclerosis and Thrombosis·Takashi HitsumotoKohji Shirai
Jun 21, 2011·Journal of Atherosclerosis and Thrombosis·Norio TadaJun Sasaki
Apr 13, 1991·BMJ : British Medical Journal·H A Neil, D Mant
Aug 1, 1989·Postgraduate Medical Journal·D Bhatnagar, P N Durrington
Jun 1, 1988·The Journal of Clinical Investigation·R J Havel
Sep 23, 1995·BMJ : British Medical Journal·W M Monique Verschuren, D Kromhout
Aug 1, 1994·Journal of Epidemiology and Community Health·P C FongY Y Sha
Sep 1, 1994·Archives of Disease in Childhood·E D PrimroseJ J Strain
Aug 1, 1993·Postgraduate Medical Journal·D M Mangion, S S Roy
Jul 13, 1996·BMJ : British Medical Journal·A AscherioW C Willett
Nov 4, 1998·Postgraduate Medical Journal·A J Coats
May 8, 1993·Quality in Health Care : QHC·T A SheldonA Long
Sep 19, 2001·British Journal of Clinical Pharmacology·S RiahiH T Sørensen
Apr 23, 2002·British Journal of Clinical Pharmacology·Aukje K Mantel-TeeuwisseAnthonius de Boer
Jun 29, 2002·BMJ : British Medical Journal·M R Law, N J Wald

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