Is renal dysfunction associated with adverse stroke outcome after thrombolytic therapy?

Cerebrovascular Diseases
Cheng-Yang HsiehChih-Hung Chen

Abstract

Renal dysfunction is a prevalent comorbidity in acute stroke patients requiring thrombolytic therapy. Reports studying the relationship between renal dysfunction and risk of postthrombolytic symptomatic intracerebral hemorrhage (SICH) are contradictory. We aimed to compare the safety and effectiveness of thrombolytic therapy in acute stroke patients with and without renal dysfunction. Based on the prospective stroke registries of 4 hospitals in Taiwan from 2007-2012, we identified acute stroke patients who received thrombolytic therapy. Clinically significant renal dysfunction was defined as an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2). Renal dysfunction was further defined as stage 3 (30 ≤ eGFR < 60 ml/min/ 1.73 m(2)), stage 4 (15 ≤ eGFR < 30 ml/min/1.73 m(2)) and stage 5 (<15 ml/min/1.73 m(2)). The rates of SICH and poor outcome (defined as modified Rankin scale score ≥4) at 3 months after thrombolytic therapy were compared in patients with and without renal dysfunction. SICH was determined according to the definition of the National Institute of Neurological Disorders and Stroke. Multivariable logistic regression was used to determine the effect of renal dysfunction on outcome. Patients with different ...Continue Reading

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Citations

Oct 6, 2015·Journal of the Neurological Sciences·Jin-Man JungSungwook Yu
Jan 13, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Cheng-Yang HsiehChih-Hung Chen
Oct 10, 2019·Journal of the American Heart Association·Zhen-Zhen RaoChinese Stroke Center Alliance investigators
Oct 31, 2017·Cerebrovascular Diseases·Mona LaibleTimolaos Rizos

Related Concepts

Cardiovascular Diseases
Cerebral Hemorrhage
Diabetes Mellitus
Dose-Response Relationship, Drug
Glomerular Filtration Rate
Lipidemias
Intravenous Infusion Procedures
Kidney Diseases
Actilyse
Proteins, Recombinant DNA

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