Is renal dysfunction associated with adverse stroke outcome after thrombolytic therapy?

Cerebrovascular Diseases
Cheng-Yang HsiehChih-Hung Chen


Renal dysfunction is a prevalent comorbidity in acute stroke patients requiring thrombolytic therapy. Reports studying the relationship between renal dysfunction and risk of postthrombolytic symptomatic intracerebral hemorrhage (SICH) are contradictory. We aimed to compare the safety and effectiveness of thrombolytic therapy in acute stroke patients with and without renal dysfunction. Based on the prospective stroke registries of 4 hospitals in Taiwan from 2007-2012, we identified acute stroke patients who received thrombolytic therapy. Clinically significant renal dysfunction was defined as an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2). Renal dysfunction was further defined as stage 3 (30 ≤ eGFR < 60 ml/min/ 1.73 m(2)), stage 4 (15 ≤ eGFR < 30 ml/min/1.73 m(2)) and stage 5 (<15 ml/min/1.73 m(2)). The rates of SICH and poor outcome (defined as modified Rankin scale score ≥4) at 3 months after thrombolytic therapy were compared in patients with and without renal dysfunction. SICH was determined according to the definition of the National Institute of Neurological Disorders and Stroke. Multivariable logistic regression was used to determine the effect of renal dysfunction on outcome. Patients with different ...Continue Reading


Dec 14, 1995·The New England Journal of Medicine·National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Jun 8, 2002·Stroke; a Journal of Cerebral Circulation·Ronald S MacWalterRouling Chen
Jun 10, 2006·Stroke; a Journal of Cerebral Circulation·Takenori YamaguchiJapan Alteplase Clinical Trial (J-ACT) Group
Aug 28, 2007·Thrombosis and Haemostasis·Jonas A SjølandJørgen Gram
Oct 27, 2007·Stroke; a Journal of Cerebral Circulation·Minesh KhatriCharles DeCarli
Dec 1, 2007·Stroke; a Journal of Cerebral Circulation·M Arfan IkramMonique M B Breteler
Dec 25, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Anetta UndasWiesława Tracz
Oct 11, 2008·Nephrology·Andrew JefferysAnnemarie Hennessy
Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Gilad YahalomDavid Tanne
Dec 1, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Varun AgrawalPeter A McCullough
Mar 13, 2010·Stroke; a Journal of Cerebral Circulation·A-Ching ChaoTaiwan Thrombolytic Therapy for Acute Ischemic Stroke (TTT-AIS) Study Group
Jul 9, 2010·Nephrology·John W M Agar
Jun 1, 2011·Contributions to Nephrology·Peter A McCullough, Robert C Maynard
Aug 16, 2011·Lancet·Andrew S Levey, Josef Coresh
Oct 11, 2012·European Heart Journal·Sumeet SharmaDiana A Gorog
Feb 23, 2013·Cerebrovascular Diseases·Albert PowerDiane Ames
May 9, 2013·Contributions to Nephrology·Teruyuki Hirano
May 17, 2013·Contributions to Nephrology·Kazunori Toyoda
Sep 5, 2013·Stroke; a Journal of Cerebral Circulation·Serdar TütüncüChristian H Nolte


Oct 6, 2015·Journal of the Neurological Sciences·Jin-Man JungSungwook Yu
Jan 13, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Cheng-Yang HsiehChih-Hung Chen
Oct 10, 2019·Journal of the American Heart Association·Zhen-Zhen RaoChinese Stroke Center Alliance investigators
Oct 31, 2017·Cerebrovascular Diseases·Mona LaibleTimolaos Rizos

Related Concepts

Cardiovascular Diseases
Cerebral Hemorrhage
Diabetes Mellitus
Dose-Response Relationship, Drug
Glomerular Filtration Rate
Intravenous Infusion Procedures
Kidney Diseases
Proteins, Recombinant DNA

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