Is retroperitoneal histology predictive of liver histology at concurrent post-chemotherapy retroperitoneal lymph node dissection and hepatic resection?

The Journal of Urology
Niels-Erik B JacobsenRichard S Foster

Abstract

We identified factors predicting liver histology in patients with nonseminomatous germ cell tumor undergoing concurrent post-chemotherapy retroperitoneal lymph node dissection and liver resection. We reviewed the Indiana University testis cancer database to identify all patients with nonseminomatous germ cell tumor and liver metastasis who underwent post-chemotherapy retroperitoneal lymph node dissection and liver resection between 1976 and 2006. A total of 59 patients met study inclusion criteria. Necrosis, teratoma and cancer were identified in 31%, 46% and 24% of retroperitoneal specimens, and in 73%, 17% and 10% of liver specimens, respectively. Concordance between retroperitoneal and liver histology was 49% overall, including 94% for necrosis, 26% for teratoma and 36% for cancer. Liver necrosis alone was found in 94%, 70% and 50% of patients with retroperitoneal necrosis, teratoma and cancer, respectively. The overall rate of histological discordance between retroperitoneal and liver histology was 51% with 73% of all liver specimens containing necrosis only. Retroperitoneal necrosis is highly predictive of hepatic necrosis (94%). Management for liver lesions at post-chemotherapy retroperitoneal lymph node dissection must b...Continue Reading

Citations

Apr 29, 2014·Der Pathologe·A HeidenreichD Pfister
Sep 4, 2012·European Urology·Siamak DaneshmandLori Wood
Nov 3, 2011·The Urologic Clinics of North America·Riley E AlexanderLiang Cheng
Apr 15, 2011·Urologic Oncology·Neda SadeghiJames M McKiernan
Jul 29, 2015·The Urologic Clinics of North America·Brian Hu, Siamak Daneshmand
Oct 20, 2018·Current Opinion in Urology·Ankeet ShahSiamak Daneshmand
Feb 23, 2019·Expert Review of Anticancer Therapy·Axel HeidenreichDavid Pfister
Dec 21, 2010·Expert Review of Anticancer Therapy·Michael C Risk, Richard S Foster
Jul 9, 2016·Current Opinion in Urology·David PfisterAxel Heidenreich
Oct 25, 2012·Deutsches Ärzteblatt International·Axel HeidenreichDavid Pfister

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