Is rheumatoid arthritis premature osteoarthritis with fetal-like healing?

Autoimmunity Reviews
Brandon P Reines

Abstract

Rheumatoid arthritis is now known to share many pathogenetic features with osteoarthritis including synovial activation with release of pro-inflammatory cytokines into the synovial fluid. As premature chondrocyte aging and dedifferentiation is increasingly accepted as integral to OA pathogenesis, premature aging of chondrocytes and perhaps subchondral bone may underlie RA. This hypothesis explains many otherwise enigmatic features of RA joint pathology such as the homing of pannus to cartilage. In addition, the surprising finding of mesenchymal precursor cells in RA joints has led to speculation that some aspect of RA pathogenesis involves an attempt to recapitulate the embryonic limb development program. In its totality, RA seems to consist of an attempt to regenerate damaged cartilage and subchondral bone in an adult organism. Since this is impossible, the best the pannus can do is to crawl through empty cartilage lacunae and replace the cartilage and subchondral bone with scar tissue. As opposed to fetal healing, inflammation is necessary to sustain and control the fibroproliferation. Two recently-discovered blood cell types seem to maintain and regulate fibroplastic states in humans: (1) CD34+ and/or monocytoid stem-cell pr...Continue Reading

References

Oct 1, 1985·Arthritis and Rheumatism·D Mitrovic
Feb 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·J de WaalJ S Maritz
Dec 1, 1999·Annals of the Rheumatic Diseases·D E FurstJ S Smolen
Dec 1, 1999·Annals of the Rheumatic Diseases·K FujiiM Tajima
Jan 10, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·B DelahuntB M Rüger
Feb 13, 2001·Current Opinion in Genetics & Development·T D Tlsty, P W Hein
Apr 4, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·F Homo-Delarche
Jan 10, 2002·Annals of the Rheumatic Diseases·M Corr, N J Zvaifler
Mar 1, 2002·Osteoarthritis and Cartilage·I SaitoT Saito
Apr 20, 2002·Virchows Archiv : an International Journal of Pathology·Peter J BarthAnnette Ramaswamy
Oct 17, 2002·The Anatomical Record·José M Pérez-Pomares, Ramón Muñoz-Chápuli
Apr 23, 2003·The American Journal of Pathology·Christian A SeemayerSteffen Gay
May 16, 2003·Nature·Gary S Firestein
Jul 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Veronika GrohThomas Spies
Sep 6, 2003·Frontiers in Bioscience : a Journal and Virtual Library·Amy S ColwellH Peter Lorenz
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marilena GrecoGiuseppe Attardi
Sep 30, 2003·Nature Immunology·Stephen P Schoenberger
Oct 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kasper J KyngVilhelm A Bohr
Oct 9, 2003·Annals of the Rheumatic Diseases·D HammakerG S Firestein
Nov 6, 2003·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·S PatilR Reid

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Citations

Aug 26, 2006·Nature Clinical Practice. Rheumatology·Gunnel NordmarkLars Rönnblom
Feb 20, 2009·Rejuvenation Research·Brandon ReinesPolly Matzinger
Jun 26, 2012·Arthritis and Rheumatism·Carole L Galligan, Eleanor N Fish
Sep 21, 2012·Journal of Leukocyte Biology·Carole L Galligan, Eleanor N Fish

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