Is rosiglitazone a promising treatment for ulcerative colitis?

Nature Clinical Practice. Gastroenterology & Hepatology
Andrew N MilestoneSubrata Ghosh

Abstract

In this Practice Point commentary, we discuss the findings and limitations of a randomized, placebo-controlled trial conducted by Lewis and colleagues that examined the efficacy of rosiglitazone for the treatment of patients with mild-to-moderately active ulcerative colitis. The results show that rosiglitazone had superior efficacy to placebo for inducing clinical response and remission. However, the efficacy of rosiglitazone in this setting was modest. We believe that this finding might be attributable to the high numbers of patients included in the trial who were refractory to conventional therapy. Rosiglitazone might be more effective if combined with 5-aminosalicylic acid therapy and used in patients with less-refractory disease. We highlight the issues to consider when interpreting and generalizing these findings to clinical practice.

References

Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessio NencioniPeter Brossart
May 6, 2003·Gastroenterology·Laurent DubuquoyPierre Desreumaux
Apr 13, 2005·The Journal of Experimental Medicine·Christel RousseauxPierre Desreumaux
Mar 9, 2007·European Journal of Pharmacology·Marina Sánchez-HidalgoCatalina Alarcón de la Lastra
Sep 13, 2007·JAMA : the Journal of the American Medical Association·Sonal SinghCurt D Furberg
Jan 8, 2008·World Journal of Gastroenterology : WJG·Hong-Liang Liang, Qin Ouyang
Mar 8, 2008·Gastroenterology·James D LewisUNKNOWN Rosiglitazone for Ulcerative Colitis Study Group

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