PMID: 9421104Jan 8, 1998Paper

Is saliva suitable for therapeutic monitoring of anticonvulsants in children: an evaluation in the routine clinical setting

Therapeutic Drug Monitoring
R GorodischerG Koren

Abstract

Studies performed in the research setting suggested that saliva instead of blood may be used for therapeutic drug monitoring (TDM) of anticonvulsants in children. This is an attractive alternative because its collection is painless, and simpler and cheaper than blood drawing. Citric acid stimulation of saliva secretion facilitates sampling in the youngest patients. The aim of the study was to evaluate the suitability of saliva in routine TDM of anticonvulsants in infants and children with epilepsy. Blood and saliva samples were obtained simultaneously during routine TDM in 170 patients on chronic anticonvulsant drug therapy attending a neurology clinic. Saliva, plasma total, and plasma free concentrations of anticonvulsants were measured by high-performance liquid chromatography and enzyme multiplied immunoassay technique. Strong and highly significant correlations between saliva and plasma concentrations were found over a wide range of concentrations for carbamazepine, phenytoin, clobazam, and desmethylclobazam, and for phenobarbital in children > or = 8 years of age (r = 0.90 to 0.97; p < 0.001). Correlations between saliva and plasma concentrations were poor for phenobarbital in children < 8 years of age and for valproate. C...Continue Reading

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Citations

Aug 25, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·P Chereches-PantaN Palibroda
Jun 24, 1999·Journal of Clinical Pharmacy and Therapeutics·E Tanaka
Apr 15, 2011·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Janet HardyBruce Charles
Jan 16, 2013·Analytical and Bioanalytical Chemistry·Baowei ChenX Chris Le
Oct 7, 2015·The International Journal of Neuroscience·Rekha DwivediManjari Tripathi
Dec 3, 2014·Seizure : the Journal of the British Epilepsy Association·Rekha DwivediManjari Tripathi
Aug 16, 2011·Journal of Pharmaceutical and Biomedical Analysis·Kwon-Bok KimJae-Gook Shin
Mar 8, 2008·Journal of Pharmaceutical and Biomedical Analysis·Michael GröschlManfred Rauh
Oct 20, 2006·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Stephen A MaloneRonald G Dickinson
May 2, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sudeep R BistaRoss Norris
Mar 15, 2015·Frontiers in Bioengineering and Biotechnology·Barbara Sanavio, Silke Krol
Apr 11, 2017·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Ken KakegawaAkitoshi Okino
Feb 15, 2018·British Journal of Clinical Pharmacology·Laura HutchinsonBridgeen Callan
May 29, 2004·Therapeutic Drug Monitoring·Michael TennisonRobert Greenwood
Jan 5, 2013·Therapeutic Drug Monitoring·Philip N Patsalos, Dave J Berry
Feb 12, 2021·European Journal of Drug Metabolism and Pharmacokinetics·Morgan PatrickSherif Hanafy Mahmoud
Mar 12, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Daniel F Chollet

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