Is salvage surgery for recurrent non-small-cell lung cancer after definitive non-operative therapy associated with reasonable survival?

Interactive Cardiovascular and Thoracic Surgery
Waldemar SchreinerHoria Sirbu

Abstract

A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was whether salvage pulmonary resection is possible and worthwhile for patients with recurrence of non-small-cell lung cancer (NSCLC) after prior definitive non-operative therapy. A total of nine reports were identified using the reported search, of which four represented the best available evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. All studies were retrospective. In total, 48 pulmonary salvage resections were performed in 47 patients after prior definitive radiation, chemoradiation or stereotactic body radiation therapy, of which 28 were lobectomies (including 1 sleeve lobectomy), 12 pneumonectomies, 4 bilobectomies and 4 sublobar resections (2 segmentectomies and 2 wedge resections). Postoperative complications ranged from 0 to 58% (mean from four studies 42.5%). Only one study reported any mortality (4%), the other three had zero mortality. Median postoperative survival was reported in two studies and ranged from 9 to 30 months. Experience with salvage lung resection...Continue Reading

References

Aug 3, 2007·Interactive Cardiovascular and Thoracic Surgery·Joel DunningKevin Mackway-Jones
Nov 26, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Fengshi ChenHiroshi Date
Nov 26, 2010·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Shinya NeriMasaki Kokubo
Apr 3, 2012·The European Respiratory Journal·Z AllibhaiA Bezjak
Apr 6, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Gregory A KuzmikAnthony W Kim
Mar 8, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hidetaka Uramoto, Fumihiro Tanaka

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Citations

Aug 1, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Alan D L Sihoe
Apr 20, 2018·Interactive Cardiovascular and Thoracic Surgery·Ludovic FournelMarco Alifano

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