Is sarcopenia a useful predictor of outcome in patients after emergency laparotomy? A study using the NELA database

Annals of the Royal College of Surgeons of England
John TrotterClare McNaught

Abstract

Introduction Studies have reported on the use of frailty as a prognostic indicator in patients undergoing elective surgery. Similar data do not exist for patients undergoing emergency surgery. The aim of this study was to evaluate the effect of preoperative sarcopenia measured by computed tomography (CT) on outcome following emergency laparotomy. Materials and methods Data from the National Emergency Laparotomy Audit database were retrieved for patients who had undergone an emergency laparotomy over 12 months at York NHS Foundation Trust. Sarcopenia was assessed by psoas density and area on preoperative CT. Mortality rates at 30 days and 1 year were recorded. Secondary outcomes included discharge rates to non-independent living. Results A total of 259 patients were included. Overall cohort 30-day and 1-year mortality was 13.9% (36/259) and 28.2% (73/259), respectively. Sarcopenia measured by psoas density was associated with increased mortality compared with patients who did not develop sarcopenia at 30 days (29.7%, 19/64, vs. 8.7%, 17/195; P < 0.001; odds ratio, OR, 4.42; 95% confidence interval, CI 2.13-9.26) and at 1 year (57.8%, 37/64, vs. 18.5%, (36/195; P < 0.001; OR 6.05; 95%CI 3.28-11.18). An increase in mortality was s...Continue Reading

References

Mar 17, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·L P FriedUNKNOWN Cardiovascular Health Study Collaborative Research Group
Feb 9, 2005·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Kenneth RockwoodIan McDowell
Mar 29, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Karen Bandeen-RocheLinda P Fried
Feb 27, 2008·Archives of Internal Medicine·Kristine E EnsrudSteven R Cummings
Jun 7, 2011·Journal of the American Medical Directors Association·John E MorleyUNKNOWN Society on Sarcopenia, Cachexia and Wasting Disorders Trialist Workshop
Feb 1, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C CooperJ-Y L Reginster
Jan 28, 2014·Journal of the American Medical Directors Association·Liang-Kung ChenHidenori Arai
Oct 21, 2014·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·K I JonesJ P Williams
Apr 30, 2015·BMJ : British Medical Journal·Caroline Fryar
Mar 21, 2016·The British Journal of Surgery·G MalietzisJ T Jenkins
Oct 8, 2016·BMC Geriatrics·Charlotte BeaudartCyrus Cooper
Dec 17, 2016·The Journal of Surgical Research·Rebecca C DirksPhilip W Smith
Feb 16, 2017·The British Journal of Surgery·J S L PartridgeJ K Dhesi

❮ Previous
Next ❯

Citations

Mar 22, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jakob BurcharthIsmail Gögenur
Nov 28, 2021·World Journal of Surgery·Zi Qin Ng, Dieter Weber

❮ Previous
Next ❯

Software Mentioned

SPSS
POSSUM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.