Is SARS-CoV-2 Spike glycoprotein impairing macrophage function via α7-nicotinic acetylcholine receptors?

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Saraiya TanmayKonstantinos Poulas


The innate immune cells play an important role in handling early infections, and can eliminate them completely up to a certain threshold. Beyond that threshold they take up their role in "The Resolution of Inflammation". The recognition of the SARS-CoV-2 antigen triggers an eicosanoid storm and initiates a robust inflammatory response. This establishes a positive feedback loop which develops into a sustained cytokine storm which interferes with the activation of adaptive immune cells. The mechanism of this interaction, and hence the pathogenesis of the virus with the immune system, is yet to be determined. In silico studies predict a direct SARS-CoV-2 spike glycoprotein interaction with nicotinic acetylcholine receptors, which could impair macrophage function and initiate the cascade of events in severe infections. We here, add to the hypothesis that immune dysregulation can be caused by the interaction of the SARS-CoV-2 spike glycoprotein via a cryptic epitope with the α7-nAChR in Type-1 macrophages, discuss its implications for the treatment of COVID-19 patients, and present better prospects for the design and dissemination of more effective vaccines and their importance.


Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·David A Hume
Mar 24, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Amanda M GuthSteven W Dow
Jun 26, 2012·Immunological Reviews·Peder S OlofssonKevin J Tracey
Apr 18, 2013·EMBO Molecular Medicine·Almudena Ortega-GómezOliver Soehnlein
Apr 15, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Carlos A Báez-PagánJosé A Lasalde-Dominicci
Jun 22, 2017·Immunity·Sangeeta S ChavanKevin J Tracey
Sep 21, 2018·International Journal of Molecular Sciences·Ekaterina NikitinaJulia Kzhyshkowska
Mar 11, 2020·Cell·Alexandra C WallsDavid Veesler
Apr 24, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Koichi YukiSophia Koutsogiannaki
May 10, 2020·Cancer Metastasis Reviews·Dipak PanigrahyBruce D Hammock
Jun 9, 2020·BioRxiv : the Preprint Server for Biology·M Gordon JoyceKayvon Modjarrad
Jun 10, 2020·Cytokine & Growth Factor Reviews·Víctor J Costela-RuizLucia Melguizo-Rodríguez
Aug 15, 2020·BioRxiv : the Preprint Server for Biology·Hejun LiuIan A Wilson
Sep 3, 2020·Cell·Naoki KanekoUNKNOWN Massachusetts Consortium on Pathogen Readiness Specimen Working Group
Jan 28, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·George LagoumintzisKonstantinos Poulas
Mar 14, 2021·Cell Reports·Chloe Rees-SpearLaura E McCoy

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.