PMID: 15360088Sep 14, 2004Paper

Is sensitization with nicotinamide and carbogen dependent on nicotinamide concentration at the time of irradiation?

International Journal of Radiation Biology
A RojasJ Denekamp

Abstract

To determine whether tumour radiosensitization and the therapeutic benefit of administering carbogen with nicotinamide depend upon irradiating at the time of peak drug concentration. Local tumour control of CaNT tumours in CBA mice and acute skin reactions in albino WHT mice were assessed after treatment with 10 X-ray fractions in air, carbogen alone or combined with 0.1, 0.2 or 0.5 mg g(-1) nicotinamide, injected 15, 30 or 60 min before irradiation. Plasma and tumour drug pharmacokinetics were performed. Nicotinamide was rapidly taken up into tumours; a six- and threefold higher concentration was obtained with 0.5 mg g(-1) compared with 0.1 and 0.2 mg g(-1), respectively. Tumour, but not skin, radiosensitization increased as the dose of nicotinamide increased (p = 0.03), but at each dose level there was no significant difference in radiosensitivity when irradiations were done at or after the time of peak concentration. An almost eightfold increase in plasma levels increased tumour enhancement ratios from 1.74 to 1.92 (p < 0.0001). In tumours all schedules gave significant enhancement relative to carbogen alone (p < or = 0.04). Tumour and skin radiosensitivity was independent of time of nicotinamide administration. Higher drug ...Continue Reading

References

Jan 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A Rojas
May 1, 1973·The British Journal of Radiology·J Denekamp
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·M R Stratford, M F Dennis
May 1, 1993·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M R HorsmanJ Overgaard
Jan 15, 1996·International Journal of Radiation Oncology, Biology, Physics·A RojasH Johns
Apr 1, 1997·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J H KaandersA Rojas
Jan 10, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M R HorsmanJ Overgaard
Jul 27, 2002·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Johan BussinkJohannes H A M Kaanders

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Citations

Apr 18, 2009·Molecular Cancer Therapeutics·James B Kirkland

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