PMID: 18723956Aug 30, 2008Paper

Is seroprevalence of anti-IGM CMV among blood donors relevant in India?

Indian Journal of Pathology & Microbiology
Harsh KumarR S Sarkar

Abstract

Infection with cytomegalovirus (CMV) is more common in developing nations and the people belonging to the lower socioeconomic section of the society. The immunosuppressed population for whom CMV-seronegative blood products are requested is increasing due to advances in medical care. To study the prevalence of CMV antibodies among the different sexes and age groups in healthy blood donors. A retrospective study was done on 5600 serum samples stored frozen in a repository for CMV antibodies using the ELISA technique. Five thousand three hundred and fifty (95.5%) were male and 250 (4.5%) were female. Four cases (0.071%) out of 5600 samples were positive for anti-IgM CMV with 95% Confidence Interval (95% C.I) of 0.02 - 0.17. In a developing country like India, screening for IgM antibody on a routine basis may not be feasible, given the likely positive yield to be low and the cost being high. It is recommended that in a tertiary care hospital, blood units to be transfused to neonates, organ transplant recipients, those suffering from malignancies and other immunocompromised patients should be screened for anti-IgM CMV or preventive strategies like universal leucodepletion to be implemented to decrease the transmission of CMV in thes...Continue Reading

Citations

Mar 29, 2014·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Bankim DasSabita Basu
Jan 18, 2017·Central European Journal of Public Health·Aleya Abdel GawadAisha El-Kayal

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