Is sialic acid an independent risk factor for cardiovascular disease? A 17-year follow-up study in Busselton, Western Australia

Annals of Epidemiology
Matthew W KnuimanMark L Divitini

Abstract

To investigate the relationship between serum sialic acid level and risk of coronary heart disease (CHD) and stroke in men and women without diagnosed cardiovascular disease. A prospective case-cohort study over the period 1981 to 1998 involving 151 CHD cases, 87 stroke cases, and a random sub-cohort of 340 was used. Sialic acid levels were determined by enzymatic method from frozen serum. Cox proportional hazards regression was used to estimate the relative risks of CHD and stroke for sialic acid tertiles and for continuous sialic acid level after adjustment for age, blood pressure, body mass index, cholesterol, triglycerides, diabetes, and smoking. The multivariate-adjusted relative risk of CHD associated with a 25 mg/dl increase in sialic acid was 1.22 (95% CI: 1.02-1.45) overall, 1.40 (95% CI: 1.11-1.76) in women, and 1.06 (95% CI: 0.82-1.37) in men. The overall relative risk for stroke was 1.13 (95% CI: 0.87-1.46) and for CHD and stroke combined it was 1.17 (95% CI: 0.99-1.37) Serum sialic acid may be a long-term predictor of CHD events in adults (especially women) who are currently clinically free of cardiovascular disease. Further studies are needed to determine whether this association can be explained by sialic acid be...Continue Reading

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Citations

Mar 1, 2006·Indian Journal of Clinical Biochemistry : IJCB·P K NigamAjay Kumar
Jun 27, 2014·Indian Journal of Clinical Biochemistry : IJCB·Vikram ThakkarMukesh Nandave
Aug 26, 2014·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·Fh YerlikayaA Arıbaş
Nov 9, 2010·Journal of Clinical Pharmacy and Therapeutics·I U RahmanM Idrees
Apr 21, 2006·Clinical Biochemistry·Karina P Gopaul, Martin A Crook
Feb 28, 2006·Thrombosis Research·Edelmiro ReganonJusto Aznar
Apr 28, 2016·Chinese Journal of Integrative Medicine·Inayat U RahmanMuhammad Iqbal Khan
Jan 9, 2014·Scientific Reports·Kolsoum InanlooRahatlooElahe Elahi
Aug 3, 2006·Physiological Genomics·Catherine CeruttiMarie-Paule Gustin
Mar 5, 2011·Pathophysiology of Haemostasis and Thrombosis·Sehkar OktayNesrin Emekli
Nov 10, 2011·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Inayat ur RahmanNaeem Ullah Jan
Jul 10, 2021·Biomarkers in Medicine·Jack CheesemanHelen Mi Osborn

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