Is signal transduction modulated by an interaction between heterotrimeric G-proteins and tubulin?

Endocrine
R Ravindra

Abstract

Although it is generally accepted that tubulin plays an important role in G-protein-mediated signal transduction in a variety of systems, the mechanism of this phenomenon is not completely understood. G-protein-tubulin interaction at the cell membrane and the cytosol, and the influence of such an interaction on cellular signaling are discussed in this review article. Because the diameter of a microtubule is 25 nm and the plasma membrane is 9-11 nm thick, it is not possible for membrane-associated tubulin to assemble into a complete microtubule in the membrane environment. However, tubulin heterodimers may be able to function in the membrane environment as individual heterodimers or as polymers arranged into short protofilaments. At the cell membrane, membrane-associated tubulin may influence hormone-receptor interaction, receptor-G-protein coupling, and G-protein-effector coupling. Structural proteins, such as tubulin, can participate in cellular signaling by communicating through physical forces. By virtue of its interaction with the submembranous network of cytoskeletal proteins, tubulin, when perturbed in one locus, can transmit large changes in conformations to other points. Thus, GTP binding to membrane-associated tubulin ...Continue Reading

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Citations

Oct 14, 2003·Biochemical Pharmacology·Andreas LinkermannOttmar Janssen
Apr 16, 2002·Journal of Neurochemistry·Julie A SaugstadP Jeffrey Conn
Mar 31, 2009·Biochimica Et Biophysica Acta·J Wolff
Oct 4, 2006·Journal of Pineal Research·Michael J JarzynkaPaula A Witt-Enderby
Apr 1, 2000·The Journal of Biological Chemistry·P PalestiniM Masserini

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