Is social support associated with post-transplant medication adherence and outcomes? A systematic review and meta-analysis

Transplantation Reviews
Keren LadinRaveendhara R Bannuru

Abstract

Although social support is used to determine transplant eligibility, the relationship between social support, medication adherence, and survival among transplant recipients remains unclear. We estimated the relationship between social support and post-transplant medication adherence and outcomes using 10 electronic databases from inception to January 2016. Study quality was assessed and all review stages were conducted independently by 2 reviewers. Systematic review and meta-analysis were conducted. Thirty-two studies (9102 participants) met inclusion criteria: 21 assessed medication adherence (5197 participants), and 13 assessed clinical outcomes (3905 participants). Among high quality studies, neither social support nor marital status was predictive of medication adherence or post-transplant outcomes. Social support was not associated with medication adherence. It was associated with superior post-transplant outcomes, but the relationship was not significant among high quality studies. Compared to unmarried recipients, married recipients were more likely to adhere to medication post-transplant, but this relationship was not significant among high quality studies. Marital status was not significantly associated with transplant...Continue Reading

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Citations

Jun 8, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Keren LadinDouglas W Hanto
Jun 16, 2018·Clinical Transplantation·Sarah Streeter HutchesonAlanna A Morris
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Oct 28, 2019·The American Journal of Bioethics : AJOB·Kelsey N BerryKeren Ladin
Oct 5, 2019·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Keren LadinDouglas W Hanto
Nov 30, 2019·Current Heart Failure Reports·Mary Amanda DewQuincy-Robyn Young
Dec 25, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ashton ChenKeren Ladin
May 26, 2018·Bone Marrow Transplantation·Tomoko SatoArinobu Tojo
Oct 6, 2020·Seminars in Dialysis·Sandheep Venkataraman, Jessica Kendrick
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May 7, 2021·Langenbeck's Archives of Surgery·Christian FazekasPeter Schemmer
Mar 7, 2021·Transplantation·Pippa BaileyEmma Massey

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