Is spindle cell oncocytoma a true entity or a variant of pituicytoma? A case report with review of literature

Neurology India
Rakesh K GuptaVikas Kumar

Abstract

Spindle cell oncocytoma (SCO) is a newly described rare entity simulating clinicoradiological features of a nonfunctional pituitary adenoma and is corresponding to the category of World Health Organization grade I tumor. However, because of the reported incidence of recurrence and invasive presentation in some cases, its categorization as a low grade tumor is questionable. Earlier, it was thought to arise from the folliculostellate cells of adenohypophysis. Recently, few reports have described expression of thyroid transcription factor-1 [TTF-1], which is a specific marker for pituicytes of neurohypophysis, suggesting this tumor to be a variant of pituicytoma. We describe a case of SCO in a 28-year-old young female patient with TTF-1 immunopositivity, and ultra-structurally showing abundant mitochondria along with few neurosecretory granules.

References

Aug 10, 2002·The American Journal of Surgical Pathology·Federico RoncaroliAllan J Yates
Aug 8, 2006·Journal of Korean Medical Science·Hyun Woo KimKyoo-Hyung Lee
Jul 5, 2008·Nature Clinical Practice. Neurology·Pasquale StrianoFederico Zara
Feb 12, 2009·Virchows Archiv : an International Journal of Pathology·Marilena VeredAmos Buchner
Jun 16, 2009·Journal of Neuropathology and Experimental Neurology·Edward B LeeNicholas K Gonatas

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Citations

Jun 20, 2019·Journal of Surgical Case Reports·Chi-Man YipPin-Pen Hsieh
Mar 14, 2019·Reviews in Endocrine & Metabolic Disorders·Fernando Guerrero-PérezCarles Villabona

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