Is stereotactic CyberKnife radiotherapy or multicatheter HDR brachytherapy the better option dosimetrically for accelerated partial breast irradiation?

Brachytherapy
Georgina FröhlichTibor Major

Abstract

To compare dosimetrically the stereotactic CyberKnife (CK) therapy and multicatheter high-dose-rate (HDR) brachytherapy (BT) for accelerated partial breast irradiation (APBI). Treatment plans of 25 patients treated with CK were selected, and additional plans using multicatheter HDR BT were created on the same CT images. The prescribed dose was 6.25/25 Gy in both plans to the target volume (PTV). The dose-volume parameters were calculated for both techniques and compared. The D90 total dose of the PTV was significantly lower with CK than with HDR BT, D90 was 25.7 Gy, and 27.0 Gy (p < 0.001). However, CK plans were more conformal than BT, COIN was 0.87, and 0.81 (p = 0.0030). The V50 of the non-target breast was higher with CK than with BT: 10.5% and 3.3% (p = 0.0010), while there was no difference in the dose of the contralateral breast and contralateral lung. Dose to skin, ipsilateral lung, and ribs were higher with CK than with BT: D1 was 20.6 Gy vs. 11.5 Gy (p = 0.0018) to skin, 11.4 Gy vs. 9.6 Gy (p = 0.0272) to ipsilateral lung and 18.5 Gy vs. 12.3 Gy (p = 0.0013) to ribs, while D0.1 to heart was lower, 3.0 Gy vs. 3.2 Gy (p = 0.0476), respectively. Multicatheter HDR BT yields more advantageous plans than stereotactic CyberK...Continue Reading

References

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Citations

Nov 2, 2021·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Tibor MajorZoltán Takácsi-Nagy

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