Is structural remodeling of fibrillated atria the consequence of tissue hypoxia?

Circulation Journal : Official Journal of the Japanese Circulation Society
Hiroshi OgiYasuki Kihara

Abstract

Matrix metalloproteinases (MMPs) play an important role in degradation of the extracellular matrix of injured tissue. MMP-9 expression increases in fibrillating atrial tissue; however, the mechanism for this increase has not been clarified. Changes in the expression of vascular endothelial growth factor (VEGF), VEGF receptors, and hypoxia-induced transcription factor-1alpha (HIF-1alpha) in fibrillating atrial tissue were investigated. Atrial tissue samples were obtained from 13 patients with atrial fibrillation (AF) and 25 patients without a history of AF (regular sinus rhythm, RSR) undergoing cardiac operations. Western blot, real-time polymerase chain reaction, and immunofluorescence analyses of the expression of VEGF, VEGF receptors, and HIF-1alpha were performed. The VEGF mRNA and protein levels increased significantly in the AF group compared with the RSR group (P<0.05), and the expression of HIF-1alpha protein was also significantly higher in the AF group. VEGF receptor-1 mRNA, a high-affinity receptor for VEGF, but not VEGF receptor-2 mRNA, was upregulated in the atria of the AF group (P<0.05). Immunofluorescence staining revealed excess production and co-localization of HIF-1alpha, VEGF and MMP-9 in the endothelium of t...Continue Reading

References

Apr 29, 1982·The New England Journal of Medicine·W B KannelP M McNamara
Oct 23, 1997·Circulation·B M PsatyP M Rautaharju
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·K SogawaY Fujii-Kuriyama
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·L E HuangH F Bunn
Mar 4, 2000·The New England Journal of Medicine·S H LeeP A Thistlethwaite
Apr 6, 2000·Journal of Applied Physiology·G L Semenza
Jul 27, 2000·Cardiovascular Research·H M van der VeldenH J Jongsma
Oct 12, 2000·Nature Cell Biology·G BergersD Hanahan
Feb 7, 2001·Circulation·M A AllessieA L Waldo
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·W ZhengR J Tomanek
Aug 31, 2001·Journal of the American College of Cardiology·L PolontchoukS Dhein
Dec 12, 2001·Journal of Molecular and Cellular Cardiology·J AusmaM Borgers
Mar 23, 2002·Circulation Research·Francis G Spinale
Jun 14, 2002·Cardiovascular Research·Maurits AllessieUlrich Schotten
Jun 14, 2002·Cardiovascular Research·Bianca J J M BrundelHarry J G M Crijns
Jun 14, 2002·Cardiovascular Research·Victor L J L ThijssenHabo J Jongsma
Sep 7, 2002·Stroke; a Journal of Cerebral Circulation·Natali A Y ChungGregory Y H Lip
Oct 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer L OwenDiana M Lopez
Mar 5, 2004·Journal of the American College of Cardiology·Yukiko NakanoKazuaki Chayama
May 25, 2005·The Journal of Cell Biology·Sunyoung LeeM Luisa Iruela-Arispe
Oct 26, 2005·Cellular Immunology·Jennifer L OwenVijaya Iragavarapu-Charyulu
Aug 1, 2006·Journal of Molecular and Cellular Cardiology·Bianca J J M BrundelHarm H Kampinga
Aug 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hiroaki NozawaDouglas Hanahan
Mar 6, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Thomas H Everett, Jeffrey E Olgin
Aug 29, 2007·Investigative Ophthalmology & Visual Science·Margrit HollbornAndreas Bringmann
Apr 12, 2008·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Alexandre MeiltzUNKNOWN Association of Cardiologists of the Canton of Geneva
Sep 6, 2008·Circulation Journal : Official Journal of the Japanese Circulation Society·Toru Oka, Issei Komuro
Feb 13, 2009·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Felix GramleyFrancesco Pezzella

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Citations

Nov 16, 2013·Current Heart Failure Reports·Reena Mehra, Susan Redline
May 18, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Wen-Chin KoLing-Ping Lai
Jul 29, 2015·International Journal of Cardiology·Christos A GoudisPanagiotis Korantzopoulos
Jan 18, 2015·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Kelly A van BragtSander Verheule
Feb 7, 2012·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Alina ScridonPhilippe Chevalier
Apr 17, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Trygve BergeArnljot Tveit
Nov 22, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Cheng-Chih ChungYi-Jen Chen
Feb 13, 2021·Molecular and Cellular Biochemistry·Savalan Babapoor-FarrokhranSumeet K Mainigi

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