Is subclinical hypothyroidism contributing dyslipidemia and insulin resistance in women with polycystic ovary syndrome?

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Cem CelikMurat Yılmaz

Abstract

We aimed to analyze lipid parameters and determine the need for a 2-hour oral glucose tolerance test (OGTT) for the identification of IR and impaired glucose tolerance test (IGT) in subclinical hypothyroidism (SCH) women with and without polycystic ovary syndrome (PCOS). 20 patients with PCOS and SCH consisted of Group I and 39 patients with PCOS and normal thyroid function consisted of Group II and 53 healthy women with normal thyroid function consisted of Group III. Triglyceride levels were 143.26 ± 99.86 mg/dL in group 1 and 88.56 ± 37.56 mg/dL in group 2 and 83.71 ± 31.94 mg/dL in group 3 which were statistically significant. Total cholesterol, HDL- cholesterol, LDL-cholesterol were found similar between the groups. Fasting insulin levels were 12.45 ± 8.62 µU/mL in group 1 and 8.60 ± 5.35 µU/mL in group 2 and 7.04 ± 3.55 µU/mL in group 3 which were statistically significant (P = 0.027). HOMA-IR were 2.92 ± 2.34 in group 1 and 1.95 ± 1.52 in group 2 and 1.60 ± 0.86 in group 3 which were statistically significant (P = 0.046). This study showed that women with PCOS and subclinical hypothyroidism should be evaluated for dyslipidemia and insulin resistance.

References

May 1, 1997·European Journal of Endocrinology·T SeppelR Schlaghecke
Jul 23, 1998·The American Journal of Medicine·D C BauerW S Browner
Mar 1, 2000·Archives of Internal Medicine·G J CanarisE C Ridgway
Sep 21, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·J E Nestler
Dec 23, 2003·Human Reproduction·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group
Jan 15, 2004·JAMA : the Journal of the American Medical Association·Martin I SurksNeil J Weissman
Jan 31, 2004·Obstetrical & Gynecological Survey·Richard S LegroRobert P Kauffman
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Ricardo AzzizBulent O Yildiz
Apr 29, 2006·European Journal of Endocrinology·G BrabantW M Wiersinga
Aug 5, 2006·Clinical Endocrinology·T M BarberS Franks
Sep 28, 2006·The Journal of Clinical Endocrinology and Metabolism·George DimitriadisSotirios A Raptis
Jun 5, 2007·Thyroid : Official Journal of the American Thyroid Association·Gabriela BrentaLaura Schreier
Sep 26, 2009·Reproductive Biomedicine Online·Ralf DittrichAndreas Mueller
Apr 17, 2010·Mediators of Inflammation·Thozhukat Sathyapalan, Stephen L Atkin
Jan 21, 2011·Fertility and Sterility·Robert A WildEnrico Carmina

❮ Previous
Next ❯

Citations

Jun 10, 2014·Indian Journal of Endocrinology and Metabolism·Syed Abbas Raza, Nasir Mahmood
Apr 29, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Rong HuangWei Liu
Jul 21, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Christian TrummerElisabeth Lerchbaum
Oct 30, 2012·Fertility and Sterility·Cristina Laguna Benetti-PintoCássia Raquel Teatin Juliato
May 14, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Yue-Hong LuHui-Fang Xu
Jul 5, 2017·Hormone Molecular Biology and Clinical Investigation·Eftihios TrakakisNikolaos Papantoniou
Nov 26, 2014·European Journal of Endocrinology·Simona GaberščekElisabeth Lerchbaum
Dec 14, 2018·Frontiers in Endocrinology·Xiaohong DingLiangshan Mu
Jul 20, 2018·Gynecologic and Obstetric Investigation·Sebastião Freitas de MedeirosMárcia Marly Winck Yamamoto
Jun 22, 2021·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Yuling XingHuijuan Ma

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.