Is symptom burden associated with treatment status and disease stage among adult HIV outpatients in East Africa?

Journal of Palliative Medicine
Eve NamisangoRichard Harding

Abstract

Symptom distress is poorly described in persons living with HIV, with limited attention paid to physical and psychological symptom prevalence to inform optimal clinical care. The study objective was to measure seven-day-period prevalence of symptoms among HIV-infected adult outpatients and determine if self-reported symptom burden is associated with antiretroviral therapy (ART), CD4 T-cell count, and clinical disease stage. Adult patients were consecutively recruited from HIV outpatient clinics at two referral and teaching hospitals in Uganda. Of 343 patients approached, 302 (88%) participated. Patients described symptoms during the previous week using the Memorial Symptom Assessment Scale Short Form, and level of physical functionality using the Karnofsky Performance Status (KPS) tool on the interview day. A high symptom burden was reported, with the most prevalent being worry (94%), feeling sad (92%), hunger (82%), feeling nervous (75%), and feeling drowsy/tired (62%). Patients with KPS scores of <70 reported more symptoms (23 versus 10; F=289.68, P<0.001) and higher symptom distress (P<0.04 for all analyses). Neither ART nor CD4 T-cell count were associated with symptom burden. WHO clinical stage 4 was associated with psycho...Continue Reading

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Citations

Jul 19, 2015·Journal of Pain and Symptom Management·Carla S AlexanderUNKNOWN Members of the AIDSRelief Consortium of PEPFAR
Feb 11, 2015·Journal of Pain and Symptom Management·Allison R WebelCarmen Portillo
Nov 11, 2017·The Journal of the Association of Nurses in AIDS Care : JANAC·Linlin LindayaniNai-Ying Ko

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