Is tau ready for admission to the prion club?

Prion
Garth F Hall, Brian A Patuto

Abstract

Aggregation-prone proteins associated with neurodegenerative disease, such as α synuclein and β amyloid, now appear to share key prion-like features with mammalian prion protein, such as the ability to recruit normal proteins to aggregates and to translocate between neurons. These features may shed light on the genesis of stereotyped lesion development patterns in conditions such as Alzheimer disease and Lewy Body dementia. We discuss the qualifications of tau protein as a possible "prionoid" mediator of lesion spread based on recent characterizations of the secretion, uptake and transneuronal transfer of human tau isoforms in a variety of tauopathy models, and in human patients. In particular, we consider (1) the possibility that prionoid behavior of misprocessed tau in neurodegenerative disease may involve other aggregation-prone proteins, including PrP itself, and (2) whether "prionlike" tau lesion propagation might include mechanisms other than protein-protein templating.

References

Oct 1, 1992·Molecular Biology of the Cell·D N DrechselM W Kirschner
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Oct 1, 1985·The Journal of Cell Biology·L I BinderL I Rebhun
May 20, 1967·Nature·T AlperM C Clarke
Dec 21, 1982·Biochemistry·S B PrusinerM P McKinley
Jul 2, 1993·Cell·H BüelerC Weissmann
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·G F HallG Lee
May 18, 1999·Molecular and Cellular Biology·M L Maddelein, R B Wickner
Sep 16, 2000·Science·S Mouillet-RichardO Kellermann
Apr 17, 2001·Neuropathology : Official Journal of the Japanese Society of Neuropathology·R A ArmstrongP L Lantos
Sep 13, 2001·The Journal of Biological Chemistry·R J PerrinJ M George
Apr 6, 2002·Acta Neuropathologica·S HaïkJ J Hauw
Apr 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Mark RapoportAdriana Ferreira
Apr 26, 2003·Science·Benoit I GiassonVirginia M-Y Lee
May 6, 2003·The Journal of Biological Chemistry·Carmen N ChiritaJeff Kuret
Jul 11, 2003·The EMBO Journal·Claire SunyachRoger Morris
Aug 20, 2003·The Journal of Cell Biology·Peter J PetersStanley B Prusiner
Oct 17, 2003·Nature·Nathan R DeleaultSurachai Supattapone
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Benoit FevrierGraça Raposo
Sep 1, 2004·Cell and Tissue Research·Heiko BraakKelly Del Tredici
Dec 24, 2004·Biochimica Et Biophysica Acta·Garth F Hall, Jun Yao
Jan 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Giuseppe LegnameStanley B Prusiner

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Citations

Dec 5, 2012·Brain : a Journal of Neurology·Ann C McKeeRobert C Cantu
Jul 3, 2013·Annual Review of Microbiology·Allison KrausByron Caughey
Jan 7, 2014·Cellular and Molecular Life Sciences : CMLS·Sean M Cascarina, Eric D Ross
Mar 17, 2015·Acta Neuropathologica Communications·Laura J BlairChad A Dickey
Apr 24, 2015·Brain Pathology·Ann C McKeeVictor E Alvarez
Apr 17, 2016·Progress in Neurobiology·Goran ŠimićPatrick R Hof
Jun 7, 2013·Communicative & Integrative Biology·Garth F Hall, Sudad Saman
Jul 10, 2016·Journal of Alzheimer's Disease : JAD·Patricia L A Leighton, W Ted Allison
Oct 11, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Botond PenkeLívia Fülöp
Apr 26, 2013·The Biochemical Journal·Maddalena Costanzo, Chiara Zurzolo
Jan 18, 2017·Cold Spring Harbor Perspectives in Medicine·Joshua KriegelAnn C McKee
Feb 24, 2017·Molecular Neurobiology·Laura UrreaJosé Antonio Del Río
Oct 23, 2019·Frontiers in Aging Neuroscience·Ena ŠpanićGoran Šimić
Aug 24, 2017·Protein Science : a Publication of the Protein Society·Bartosz NizynskiKrzysztof Nieznanski
Sep 10, 2021·Journal of Neuropathology and Experimental Neurology·Analiese R FernandesMatthew P Frosch

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