Is the acetylcholine releasing protein mediatophore present in rat brain?

FEBS Letters
M IsraëlG Le Gal la Salle

Abstract

Mediatophore is a protein purified from the nerve terminal membranes of Torpedo electric organ. It confers to artificial membranes a calcium-dependent mechanism that translocates acetylcholine. When similar reconstitution experiments are applied to rat brain synaptosomal membranes they reveal the presence of mediatophore activity with properties close to those described for the Torpedo protein (extractability, sensitivity to calcium, and effect of the drug cetiedil). The activity was more abundant in synaptosomal membranes than in mitochondrial or myelinic membranes and in cholinergic areas as compared to cerebellum.

References

Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M IsraëlR Manaranche
Aug 1, 1987·Journal of Neurochemistry·Y M Gaudry-TalarmainN Morel
May 1, 1972·Analytical Biochemistry·M B Lees, S Paxman
Jan 1, 1965·Progress in Biophysics and Molecular Biology·V P Whittaker
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M IsraëlJ C Dedieu
May 15, 1982·The Biochemical Journal·R G King, R M Marchbanks

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Citations

Apr 29, 1998·Molecular Neurobiology·M Israël, Y Dunant
Jan 1, 1993·Journal of Physiology, Paris·Y Dunant, M Israël
Dec 31, 1997·Neurochemistry International·Y Dunant, M Israël
Oct 1, 1992·The European Journal of Neuroscience·B. Palouzier-PaulignanJ.-P. Ternaux
Nov 1, 1990·Journal of Neurochemistry·M IsraëlN Morel

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