PMID: 3514408Mar 1, 1986

Is the acidity of ascitic fluid a reliable index in making the presumptive diagnosis of spontaneous bacterial peritonitis?

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
G PinzelloL Pagliaro

Abstract

Ascitic fluid pH and arterial-ascitic fluid pH gradient were compared to ascitic fluid polymorphonuclear cell count in 84 patients with cirrhotic ascites and in 12 with malignant ascites to assess their role as diagnostic tests for spontaneous bacterial peritonitis and to clarify the relationship between ascitic fluid pH and lactate. Ascitic fluid pH was significantly lower (pH 7.30) in spontaneous bacterial peritonitis (n = 18) and probable spontaneous bacterial peritonitis (n = 12) than in sterile ascites (pH 7.41; n = 54). Since blood pH levels were not different in the presence of infection, arterial-ascitic fluid pH gradient was significantly higher in spontaneous bacterial peritonitis and probable spontaneous bacterial peritonitis than in sterile ascites (0.12 vs. 0.02). The close correlations between arterial-ascitic pH gradient and lactate (r = 0.77, p less than 0.0001), lactate and bicarbonate gradient (r = 0.64, p = 0.003) and arterial-ascitic pH gradient and pCO2 gradient (r = -0.90, p less than 0.0001) suggest that the low ascitic fluid pH may be due to an increase in lactate and CO2. Patients with Escherichia coli-induced spontaneous bacterial peritonitis had significantly lower ascitic fluid pH and higher lactate ...Continue Reading

References

Sep 1, 1978·Archives of Internal Medicine·D E PottsS A Sahn
Feb 1, 1979·Digestive Diseases and Sciences·S Bar-MeirH O Conn
Jan 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C Y YangI S Sheen
Jan 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G Garcia-TsaoE Lerner
Nov 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B A Runyon, J C Hoefs
Jul 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N GitlinR C Silvestri

Citations

Jan 1, 1989·Baillière's Clinical Gastroenterology·R J Wyke
Apr 1, 1987·Scandinavian Journal of Gastroenterology·T P Almdal, P Skinhøj
Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L TitóJ Rodés
Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B A Runyon
May 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B A Runyon, M R Antillon
May 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N Gitlin
Aug 1, 1993·Cancer·A ColliG Buccino
Jan 1, 1995·Scandinavian Journal of Gastroenterology·J L Sánchez-LombrañaL Rodrigo
Nov 13, 2004·Anaesthesia and Intensive Care·B Dixon

Related Concepts

Ascites
Peritoneal Fluid (Body Substance)
Bacterial Infections
Escherichia Coli Infections
Hydrogen-Ion Concentration
Lactates
Differential White Blood Cell Count Procedure
Fibrosis, Liver
Neutrophil Band Cells
Peritoneal Neoplasms

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