Is the bispectral index appropriate for monitoring the sedation level of mechanically ventilated surgical ICU patients?

Intensive Care Medicine
Dirk FrenzelNorbert Roewer

Abstract

To determine the value of the bispectral index (BIS) in assessing the depth of sedation in sedated and mechanically ventilated ICU patients, compared with clinical sedation scores. Prospective convenience sample in a 12-bed anesthesiological-surgical ICU of a university hospital. 19 consecutive patients without any central neurological diseases requiring mechanical ventilation for more than 24 h. BIS version 3.12 and clinical depth of sedation assessed by the modified Observers's Assessment of Alertness/Sedation Scale, modified Glasgow Coma Scale, modified Ramsay Scale, Cook Scale, and Sedation-Agitation Scale were measured twice daily while patients were intubated and once daily after extubation until discharged from ICU. there was a moderate correlation between BIS and each sedation score in 11 patients (58%, "BIS patients") and no correlation in 8 patients (42%, "non-BIS patients"). We found no parameters distinguishing between these two groups. On average eight measurements were necessary to establish a statistical correlation. In the BIS patients the slopes of the linear regression curves showed significant differences for all BIS score combinations with increasing scattering at deeper sedation levels. BIS is correlated on...Continue Reading

Associated Clinical Trials

Jun 14, 2013·Juhani Akseli Stewart

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