Is the circulating urokinase plasminogen activator upregulated by the circulating p105 fraction of the HER-2/neu proto-oncogene in patients with cervical cancer?

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Diana N ContrerasCharles Lox

Abstract

It has been suggested that urokinase plasminogen activator (uPA) in cancer cells is upregulated by the p185 kD form of the HER-2/neu oncogene. This study was performed to see if the extracellular domain of HER-2/neu, the p105 fraction, which is found in the circulation, has any regulatory influence on uPA in patients with cervical cancer. Levels of uPA and p105 HER-2/neu were determined in blood from age-matched controls and patients with early and advanced cervical cancer. In the patients with cervical cancer, samples were obtained before treatment only. No significant increase in either uPA or HER-2/neu was seen in the patients before their treatment for cervical cancer. Additionally, correlation analysis of circulating uPA and HER-2/neu against each other in both the controls and cervical cancer indicated no relationship except in early stage disease. It appears that circulating uPA and HER-2/neu are not altered in patients with cervical cancer, either early or advanced stages. The upregulation of uPA by HER-2/neu seen in cancer cells in vitro appears to occur in vivo in early stage cervical cancer.

References

Jul 1, 1991·Seminars in Thrombosis and Hemostasis·H C KwaanR Ernst
May 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K LeitzelA Lipton
Jan 1, 1994·Journal of Cancer Research and Clinical Oncology·H MedenW Kuhn
Sep 4, 1996·International Journal of Cancer. Journal International Du Cancer·T L MoserM S Stack
May 1, 1996·Journal of the Society for Gynecologic Investigation·F D Cirisano, B Y Karlan
Jan 1, 1997·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·R MolinaA M Ballesta
Apr 1, 1997·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L M TeranD E Davies
Aug 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A Daneri-NavarroS Orbach-Arbouys
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·L N KlapperY Yarden
Jul 3, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·H W NijmanC J Meijer
Aug 26, 1999·Gynecologic and Obstetric Investigation·T H CheungA M Chang

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