Is the clinical lipidomics a potential goldmine?

Cell Biology and Toxicology
Linlin ZhangXiangdong Wang

Abstract

Clinical lipidomics is a new extension of lipidomics to study lipid profiles, pathways, and networks by characterizing and quantifying the complete lipid molecules in cells, biopsy, or body fluids of patients. It undoubtfully has more values if lipidomics can be integrated with the data of clinical proteomic, genomic, and phenomic profiles. A number of challenges, e.g., instability, specificity, and sensitivity, in lipidomics have to be faced and overcome before clinical application. The association of lipidomics data with gene expression and sequencing of lipid-specific proteins/enzymes should be furthermore clarified. Therefore, clinical lipidomics is expected to be more stable during handling, sensitive in response to changes, specific for diseases, efficient in data analyses, and standardized in measurements, in order to meet clinical needs. Clinical lipidomics will become a more important approach in clinical applications and will be the part of "natural" measures for early diagnosis and progress of disease. Thus, clinical lipidomics will be one of the most powerful approaches for disease-specific diagnosis and therapy, once the mystery of lipidomic profiles and metabolic enzymes is deciphered.

References

Nov 21, 2014·Journal of Inherited Metabolic Disease·Frédéric M VazAntoine H C van Kampen
Sep 24, 2015·Journal of Separation Science·Li YangHuwei Liu
Jul 14, 2016·Cell Biology and Toxicology·Xiangdong Wang
Jul 30, 2016·Nature Reviews. Endocrinology·Xianlin Han
Oct 30, 2016·Trends in Biochemical Sciences·Kui Yang, Xianlin Han
Nov 24, 2017·Cell Biology and Toxicology·Zhongyi ZhuYong Hou
Mar 16, 2018·Frontiers in Neurology·Woojin Scott KimGlenda M Halliday
Apr 25, 2018·Cell Biology and Toxicology·Xiangdong Wang
Apr 29, 2018·Clinical and Translational Medicine·Jiapei LvXiangdong Wang
Jul 13, 2018·Journal of Cellular and Molecular Medicine·Jiapei LvXiangdong Wang

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Citations

Nov 11, 2019·Rapid Communications in Mass Spectrometry : RCM·Yunong Li, Liang Li
Jun 9, 2020·Clinical and Translational Medicine·Furong YanYiming Zeng
Mar 1, 2019·Cell Biology and Toxicology·Dongli SongXiangdong Wang

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