Is the concentration of C-reactive protein in bacteraemia associated with age?

Immunity & Ageing : I & a
Astrid L WesterTorgeir Bruun Wyller

Abstract

C-reactive protein (CRP) is an indicator of inflammation, and is often used in the diagnosis of bacterial infections. It is poorly known whether CRP in bacterial infection is age-dependent. Adult patients with a positive blood culture with E. coli or S. pneumoniae during 1994-2004 were included. CRP measured on the same date as the blood cultures were drawn (CRP1), 2-3 days (CRP2) and 4-7 days later (CRP3), were retrieved. The patients were divided into three age groups, < 65, 65-84, and > or = 85, respectively. We studied three cut-off values for CRP and produced age-specific receiver operating characteristics (ROC) curves, using patients with acute coronary or cerebral infarction as controls. 890 patients and 421 controls were available. There was a statistically significant negative correlation between age and CRP1 - 0.072 (p = 0.032). The median CRP1 and CRP2 were significantly higher in the youngest age group. The area under the ROC-curve for the youngest age group was significantly greater than that of the two other age groups, but we found no statistically significant differences in sensitivity related to age. The diagnostic sensitivity of CRP was better for S. pneumoniae than for E. coli, 92.6% vs. 88.0% (p = 0.046) for...Continue Reading

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Citations

Jan 12, 2013·International Urology and Nephrology·Ali MonfaredNazly Amini
Jan 24, 2013·Case Reports in Gastroenterology·Ioannis KoutsounasCharalambos Barbatzas
Sep 10, 2015·Journal of Crohn's & Colitis·A de Buck van OverstraetenA D'Hoore
Jun 17, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·L A van VughtT van der Poll
Sep 4, 2015·Zeitschrift für Gerontologie und Geriatrie·Thomas BertschHans Jürgen Heppner
Sep 1, 2017·Aging Clinical and Experimental Research·Omer KarasahinSevnaz Sahin
Apr 30, 2009·Anaesthesia and Intensive Care·K M Ho, J Lipman

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Methods Mentioned

BETA
blood drawn

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