Is the difference in outcome between men and women treated by primary percutaneous coronary intervention age dependent? Gender difference in STEMI stratified on age

European Heart Journal. Acute Cardiovascular Care
Amber M OttenZwolle Myocardial Infarction study Group

Abstract

Poorer outcomes in women with ST-elevation myocardial infarction (STEMI) are often attributed to gender differences in baseline characteristics. However, these may be age dependent. We examined the importance of gender in separate age groups of patients with STEMI undergoing primary percutaneous coronary intervention (PPCI). Data of 6746 consecutive patients with STEMI admitted for PPCI between 1998 and 2008 in our hospital were evaluated. Age was stratified into two groups, <65 years (young group) and ≥65 years (elderly). Endpoints were enzymic infarct size as well as 30-day and 1 year mortality. We studied a total of 4991 (74.0%) men and 1755 (26.0%) women; 40% of women were <65 years and 60% of men were <65 years of age. In the elderly group (≥65 years), women had more frequently diabetes and hypertension while they smoked less frequently than men. Younger women smoked more often than similarly aged men and had more hypertension. At angiography, single-vessel disease and TIMI 3 flow before PPCI was more present in younger women than men, whereas these differences were not found in the older age group. Patient delay before admission was shorter in men at all ages, while women had lower creatine kinase levels. Younger women ha...Continue Reading

References

Apr 4, 1985·The New England Journal of Medicine·UNKNOWN TIMI Study Group
Apr 29, 1998·BMJ : British Medical Journal·E PrescottJ Vestbo
Jun 11, 1999·The New England Journal of Medicine·M E Mendelsohn, R H Karas
Sep 8, 2001·The American Journal of Cardiology·E D PetersonUNKNOWN National Cardiovascular Network Clinical Investigators
Dec 26, 2001·The New England Journal of Medicine·B C TanisF R Rosendaal
Feb 11, 2003·Journal of the American College of Cardiology·C Noel Bairey MerzUNKNOWN WISE Study Group
Jan 27, 2005·JAMA : the Journal of the American Medical Association·Raffaele Bugiardini, C Noel Bairey Merz
May 5, 2005·JAMA : the Journal of the American Medical Association·Ioannis IakovouAntonio Colombo
Sep 20, 2006·Circulation·Karen P AlexanderUNKNOWN CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of th
Oct 24, 2006·The American Journal of Cardiology·Jeffrey S Berger, David L Brown
Jun 14, 2008·Journal of the American College of Cardiology·Mandeep SinghDavid R Holmes
Dec 10, 2008·Circulation·Hani JneidUNKNOWN Get With the Guidelines Steering Committee and Investigators
Feb 28, 2009·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Morten GrundtvigAsmund Reikvam
Aug 27, 2009·JAMA : the Journal of the American Medical Association·Jeffrey S BergerPamela S Douglas
Oct 13, 2009·Journal of the American College of Cardiology·Miranda C A KramerRenu Virmani
Oct 17, 2009·Journal of the American College of Cardiology·Leslee J ShawC Noel Bairey Merz
Dec 28, 2010·European Heart Journal·Erik IngelssonDaniel Altman
Feb 3, 2011·Cardiovascular Research·Silvia S BarbieriElena Tremoli
Mar 12, 2011·European Heart Journal·C Noel Bairey Merz
Apr 27, 2011·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Hakim BenamerUNKNOWN CARDIO-ARHIF Registry Investigators
Feb 24, 2012·JAMA : the Journal of the American Medical Association·John G CantoUNKNOWN NRMI Investigators
Jun 15, 2012·The New England Journal of Medicine·Øjvind LidegaardNiels Keiding

❮ Previous
Next ❯

Citations

Nov 5, 2015·European Heart Journal·UNKNOWN EUGenMed Cardiovascular Clinical Study GroupVerena Stangl
Jun 26, 2015·Wiener klinische Wochenschrift·Andreja SinkovičAndrej Markota
Aug 19, 2015·American Journal of Obstetrics and Gynecology·Joel G RayMarian J Vermeulen
Jul 15, 2015·International Journal of Cardiology·Chirag BavishiJacqueline E Tamis-Holland
Feb 17, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Janet Wei, Timothy D Henry
May 27, 2015·Maturitas·Suzette E Elias-SmaleAngela H E M Maas
Apr 9, 2016·JACC. Cardiovascular Imaging·Jaya Chandrasekhar, Roxana Mehran
Feb 24, 2015·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Lorenza Michela BiavaSebastiano Marra
Jun 4, 2016·Nature Reviews. Cardiology·Neha J Pagidipati, Eric D Peterson
Oct 27, 2016·Hellenic Journal of Cardiology : HJC = Hellēnikē Kardiologikē Epitheōrēsē·Stefanos Foussas
Jun 3, 2015·Angiology·Genovefa D Kolovou, Sophie Mavrogeni
Mar 31, 2016·Journal of Cardiovascular Medicine·Silvia ZagnoniUNKNOWN MANTRA Investigators
Feb 27, 2018·Clinical Cardiology·Janine A Clayton, Matthew E Arnegard
Feb 18, 2016·Clinical Medicine Insights. Cardiology·Garth Graham
Oct 6, 2017·European Heart Journal. Acute Cardiovascular Care·Arvindra KrishnamurthyJohn P Greenwood
Apr 19, 2018·Clinical Cardiology·Eva FreisingerKarl Wegscheider
Jun 8, 2018·Coronary Artery Disease·Leor PerlJan B Pietzsch
Jan 27, 2016·Circulation·Laxmi S MehtaUNKNOWN American Heart Association Cardiovascular Disease in Women and Special Populations Committee of the Council on Clinical Card
Jan 17, 2019·Journal of the American Heart Association·Katherine MooreIsuru Ranasinghe
Dec 7, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Estelle VautrinJosé Labarère
Jan 15, 2020·Heart·Julinda Mehilli, Patrizia Presbitero
May 11, 2017·Revista da Associação Médica Brasileira·Lucas Colombo GodoyCarlos V Serrano
Dec 6, 2017·Menopause : the Journal of the North American Menopause Society·Karolina Ewa KryczkaBarbara Lubiszewska
Apr 17, 2019·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M E Ten HaafY Appelman
Jun 13, 2020·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·T KerkmanY Appelman
May 27, 2020·Cardiology Research and Practice·Shi TaiShenghua Zhou
Aug 28, 2018·Korean Circulation Journal·Vera Regitz-Zagrosek

❮ Previous
Next ❯

Methods Mentioned

BETA
coronary artery bypass
hormone replacement therapy

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.