Is the enthesitis-related arthritis subtype of juvenile idiopathic arthritis a form of chronic reactive arthritis?

Rheumatology
N SaxenaA Aggarwal

Abstract

Enteric organisms are known to trigger reactive arthritis. The enthesitis-related arthritis (ERA) form of juvenile idiopathic arthritis (JIA) clinically resembles reactive arthritis. Therefore, we looked for a role of enteric bacteria in ERA. Synovial fluid (SF) was obtained from 26 patients with ERA and 10 patients with rheumatoid arthritis (RA). Blood specimens were also obtained from patients with ERA and from 10 normal individuals. Lymphocyte proliferation assays were done on whole blood and SF mononuclear cells using as antigens crude lysates of the enteric bacteria Salmonella typhimurium, Yersinia enterocolitica, Shigella flexneri and Campylobacter jejuni. Crude lysate of Escherichia coli was used as a control antigen. HLA-B27 typing was done using the polymerase chain reaction. Homing of gut-specific T cells (CD103+) to the synovial compartment was studied using tri-colour flow cytometry. The antigen-specific cytokine profile was determined by flow cytometry. Antigen-specific lymphoproliferative responses were observed in 14 of 26 patients. Among these patients, 12 showed a response in SF (four each to S. typhimurium and C. jejuni, and in two each to S. flexneri and Y. enterocolitica), and two patients in blood (S. typhi...Continue Reading

References

Oct 1, 1990·European Journal of Immunology·P J Kilshaw, S J Murant
Sep 1, 1987·European Journal of Immunology·N Cerf-BensussanC Griscelli
Jan 1, 1994·Rheumatology International·A Aggarwal, R Misra
Nov 5, 1997·British Journal of Rheumatology·A AggarwalA Ayyagari
Sep 25, 1998·Current Opinion in Rheumatology·J N Jarvis
Jul 26, 2000·Current Opinion in Rheumatology·A Toivanen, P Toivanen
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi

❮ Previous
Next ❯

Citations

May 8, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M P RiggioJeremy Bagg
May 13, 2008·Modern Rheumatology·Yogesh Preet SinghRamnath Misra
Feb 12, 2014·Current Rheumatology Reports·Anand N MalaviyaUma Kanga
Nov 26, 2009·Autoimmunity Reviews·Yackov Berkun, Shai Padeh
Aug 6, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Priyanka GaurAmita Aggarwal
Aug 4, 2015·Clinical Rheumatology·Amita Aggarwal, Durga Prasanna Misra
Sep 23, 2014·Joint, Bone, Spine : Revue Du Rhumatisme·Jean-Marie BerthelotRégis Josien
Dec 16, 2016·Journal of Pediatric Ophthalmology and Strabismus·Christopher J LyonsJane Gardiner
May 12, 2017·Nature Reviews. Rheumatology·Ramnath Misra, Latika Gupta
Nov 12, 2014·Clinical Reviews in Allergy & Immunology·Donato RiganteSusanna Esposito
Dec 14, 2019·Immunological Reviews·Miika ArvonenMatthew L Stoll

❮ Previous
Next ❯

Related Concepts

Related Feeds

Campylobacteriosis

Campylobacteriosis is caused by the bacteria Campylobacter jejuni and is a common cause of gastroenteritis in humans. Discover the latest research on Campylobacteriosis here.

Campylobacteriosis (ASM)

Campylobacteriosis is caused by the bacteria Campylobacter jejuni and is a common cause of gastroenteritis in humans. Discover the latest research on Campylobacteriosis here.