Is the formula of Traub still up to date in antemortem blood glucose level estimation?

International Journal of Legal Medicine
Cristian PalmierePatrice Mangin

Abstract

According to the hypothesis of Traub, also known as the 'formula of Traub', postmortem values of glucose and lactate found in the cerebrospinal fluid or vitreous humor are considered indicators of antemortem blood glucose levels. However, because the lactate concentration increases in the vitreous and cerebrospinal fluid after death, some authors postulated that using the sum value to estimate antemortem blood glucose levels could lead to an overestimation of the cases of glucose metabolic disorders with fatal outcomes, such as diabetic ketoacidosis. The aim of our study, performed on 470 consecutive forensic cases, was to ascertain the advantages of the sum value to estimate antemortem blood glucose concentrations and, consequently, to rule out fatal diabetic ketoacidosis as the cause of death. Other biochemical parameters, such as blood 3-beta-hydroxybutyrate, acetoacetate, acetone, glycated haemoglobin and urine glucose levels, were also determined. In addition, postmortem native CT scan, autopsy, histology, neuropathology and toxicology were performed to confirm diabetic ketoacidosis as the cause of death. According to our results, the sum value does not add any further information for the estimation of antemortem blood glu...Continue Reading

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Citations

Jun 1, 2013·International Journal of Legal Medicine·Cristian PalmiereDominique Werner
Jun 27, 2013·International Journal of Legal Medicine·J PirchM Klintschar
Oct 5, 2013·International Journal of Legal Medicine·Terhi KeltanenKatarina Lindroos
Nov 10, 2013·International Journal of Legal Medicine·Alessandro BonsignoreCristian Palmiere
Jan 23, 2016·Forensic Science International : Synergy·T SchäferL Hagemeier
Jan 30, 2013·Forensic Science International : Synergy·Cristian PalmiereDominique Werner
Apr 14, 2012·Legal Medicine·Cristian Palmiere, Patrice Mangin
Sep 14, 2015·Forensic Science International : Synergy·C HessB Madea
Oct 12, 2013·Journal of Forensic and Legal Medicine·Cristian PalmiereDominique Werner
Mar 29, 2014·Journal of Forensic Sciences·Cristian PalmiereJohannes A Lobrinus
Oct 16, 2015·International Journal of Legal Medicine·T KeltanenK Lindroos
Jun 28, 2016·Forensic Science International : Synergy·Anna-Mari WaltaAntti Sajantila
Jun 20, 2020·International Journal of Legal Medicine·Pierre-Antoine PeyronJean-Paul Cristol
Nov 25, 2017·International Journal of Legal Medicine·Jakob HeimerNiklaus Zoelch
Jan 13, 2017·International Journal of Legal Medicine·Xin-Yi JiYan-Yan Fan
Mar 15, 2020·Forensic Science International : Synergy·Nicola PigaianiFranco Tagliaro

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