Is the genetic liability in multifactorial disorders higher in concordant than discordant monozygotic twin pairs? A population-based family twin study of migraine without aura

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
M GervilM B Russell

Abstract

Migraine without aura (MO) is a multifactorial disorder. Expression of a disorder with multifactorial inheritance depends on the genetic liability and on environmental factors. A high liability is reflected by a high frequency of affected relatives. We have previously shown that monozygotic (MZ) twin pairs have a significant higher concordance of MO than dizygotic twin pairs. The incomplete concordance among MZ twin pairs may be due to a lower genetic liability among discordant than concordant MZ twin pairs. The present study analysed the genetic liability in MZ twin pairs concordant and discordant for MO by the population-relative risk of MO among parents and siblings. The twin pairs were from the population-based Danish Twin Register. First-degree relatives of 29 concordant and 34 discordant MZ twin pairs were blindly telephone interviewed by a physician. The participation rate of the eligible first-degree relatives was 96%. The population-relative risk of MO among parents and siblings was 2.73 (2.39-3.06) in concordant and 2.37 (2.03-2.71) in discordant MZ twin pairs. The relative risk of MO was significantly higher in female first-degree relatives of concordant than of discordant MZ male and female twin pairs. An opposite e...Continue Reading

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Citations

Feb 20, 2008·Mutation Research·Kari HemminkiJan Sundquist
Jan 9, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A-L EsserlindJ Olesen
Jun 5, 2003·Cephalalgia : an International Journal of Headache·Da SvenssonE Waldenlind
Feb 10, 2017·Physiological Reviews·Peter J GoadsbySimon Akerman

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