PMID: 9417171Jan 7, 1998Paper

Is the incidence of appendicitis reduced in patients with sickle cell disease?

Pediatrics
P AntalB Berman

Abstract

Patients with sickle cell disease (SCD) often present with abdominal pain, usually attributable to vasoocclusion. Experience at a single institution suggested that appendicitis was a rare cause of abdominal symptoms in this population. We sought to determine whether the incidence of appendicitis was significantly lower in patients with SCD than in the population at large. A 17-year retrospective chart review was performed at Rainbow Babies and Children's Hospital, Cleveland, OH, to determine the approximate incidence of acute appendicitis (AA) in patients with SCD. In addition, we performed a statistical analysis comparing the incidence of AA among SCD patients enrolled in the Cooperative Study of Sickle Cell Disease with that in the general population. Only two patients with SCD with pathologically confirmed AA were identified among approximately 200 patients followed at our institution during a 17-year period ( approximately 3500 patient-years), yielding an incidence rate of 5.7 cases per 10 000 patient-years. Among 3765 patients with SCD enrolled in the Cooperative Study of Sickle Cell Disease followed for a mean of 5.3 years (19 886 patient-years), a maximum of 9 cases of AA were identified, yielding an incidence rate of 4....Continue Reading

Citations

Jul 14, 2001·Radiographics : a Review Publication of the Radiological Society of North America, Inc·G J LonerganS L Abbondanzo
Jul 20, 2002·Inflammatory Bowel Diseases·Ioannis E KoutroubakisElias A Kouroumalis
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Oct 24, 2020·Journal of the American College of Radiology : JACR·Stephanie B ShamirMark C Liszewski

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