Is the incidence of psychotic disorder in decline? Epidemiological evidence from two decades of research.

International Journal of Epidemiology
James B KirkbridePeter B Jones

Abstract

It is unclear whether the incidence of first episode psychoses is in decline. We had the opportunity to determine whether incidence had changed over a 20-year period in a single setting, and test whether this could be explained by demographic or clinical changes. The entire population at-risk aged 16-54 in Nottingham over three time periods (1978-80, 1993-95 and 1997-99) were followed up. All participants presenting with an ICD-9/10 first episode psychosis were included. The remainder of the population at-risk formed the denominator. Standardized incidence rates were calculated at each time period with possible change over time assessed via Poisson regression. We studied six outcomes: substance-induced psychoses, schizophrenia, other non-affective psychoses, manic psychoses, depressive psychoses and all psychotic disorders combined. Three hundred and forty-seven participants with a first episode psychosis during 1.2 million person-years of follow-up over three time periods were identified. The incidence of non-affective or affective psychoses had not changed over time following standardization for age, sex and ethnicity. We observed a linear increase in the incidence of substance-induced psychosis, per annum, over time (inciden...Continue Reading

References

Oct 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·P Munk-Jørgensen, P B Mortensen
Jan 1, 1992·Psychological Medicine. Monograph Supplement·A JablenskyA Bertelsen
Dec 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·D CastleR M Murray
Dec 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·G HarrisonR Gancarczyk
Mar 3, 1990·Lancet·G DerR M Murray
Jun 1, 1988·The British Journal of Psychiatry : the Journal of Mental Science·J M EaglesC McCance
Nov 1, 1987·The British Journal of Psychiatry : the Journal of Mental Science·J E CooperJ Korer
Jul 1, 1982·Archives of General Psychiatry·N C Andreasen
Nov 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·J R GeddesJ M Eagles
Feb 1, 1993·The British Journal of Psychiatry : the Journal of Mental Science·R E KendellW Adams
Jan 1, 1993·European Archives of Psychiatry and Clinical Neuroscience·P Munk-Jørgensen, P B Mortensen
Jun 1, 1996·Social Psychiatry and Psychiatric Epidemiology·J van OsR M Murray
Aug 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·J BrewinG Harrison
Apr 22, 1999·The British Journal of Psychiatry : the Journal of Mental Science·R CantwellG Harrison
Aug 6, 1999·Archives of General Psychiatry·J M SuvisaariJ K Lönnqvist
Aug 17, 2000·The British Journal of Psychiatry : the Journal of Mental Science·J AllardyceR G McCreadie
Nov 26, 2002·BMJ : British Medical Journal·Louise ArseneaultTerrie E Moffitt
Jan 2, 2003·The British Journal of Psychiatry : the Journal of Mental Science·J BoydellR M Murray
Aug 30, 2006·Psychological Medicine·Paul FearonUNKNOWN AESOP Study Group
May 3, 2007·Psychological Medicine·James B KirkbridePeter B Jones

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Citations

Jan 24, 2013·Social Psychiatry and Psychiatric Epidemiology·Arjen L SutterlandMiriam C J M Sturkenboom
Jun 2, 2011·The British Journal of Psychiatry : the Journal of Mental Science·Nicola SwinsonJenny Shaw
Feb 5, 2011·Social Psychiatry and Psychiatric Epidemiology·Antonio LoraMauro Percudani
Sep 30, 2015·Social Psychiatry and Psychiatric Epidemiology·Alvaro Medel-HerreroM Gómez-Beneyto
Apr 17, 2012·PloS One·Yi-Ning YangYou Chen
Feb 23, 2020·Journal of Epidemiology and Community Health·Jerzy Eisenberg-Guyot, Anjum Hajat
May 22, 2020·Irish Journal of Psychological Medicine·B O'DonoghueP McGorry
Sep 21, 2018·International Journal of Methods in Psychiatric Research·Baptiste PignonAndrei Szöke
Oct 24, 2020·Current Medical Research and Opinion·Benedicto Crespo-FacorroRichard Newton
Mar 14, 2021·Acta Psychiatrica Scandinavica·Antti TanskanenJari Tiihonen
Apr 26, 2021·Schizophrenia Research·Baptiste PignonBrian O'Donoghue

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