PMID: 11908511Mar 23, 2002Paper

Is the increase in bronchial responsiveness or FEV1 shortly after cessation of beta2-agonists reflecting a real deterioration of the disease in allergic asthmatic patients? A comparison between short-acting and long-acting beta2-agonists

Respiratory Medicine
C P van SchayckC van Weel

Abstract

Regular use of beta2-agonists might result in increased bronchial hyper-responsiveness (BHR) and decreased forced expiratory volume in 1 sec (FEV1). It has been suggested that these possible detrimental effects are not a real deterioration of the disease, but that it might be only a transient (rebound) effect shortly after discontinuing this regular use. Moreover, these effects are thought to occur especially during short-acting and not during long-acting beta2-agonists use. The aim of this study was to invest gate whether a rebound effect (a pharmacological deterioration effect diminishing after several hours) in FEV1 and PC20 (concentration of histamine causing a 20% fall in FEV1 with regard to baseline) occurred after cessation of regular use of beta2-agonists, and whether this occurred both after short-acting and long-acting beta2-agonists. Allergic asthmatic patients (n = 134) were randomly allocated to the use of a short-acting (salbutamol), a long-acting beta2-agonist (formoterol) or placebo for 12 weeks (double-blind, double-dummy). No other asthma medication was allowed, including inhaled corticosteroids. At the start and every 4 weeks later FEV and PC20 were measured, each time at least 12 h after the last doses of st...Continue Reading

Citations

Jun 14, 2003·The Cochrane Database of Systematic Reviews·E H Walters, J Walters
Apr 20, 2012·The Cochrane Database of Systematic Reviews·Christopher J Cates, Matthew J Cates
Oct 4, 2006·Homeopathy : the Journal of the Faculty of Homeopathy·M Z Teixeira
Sep 2, 2006·Pharmacotherapy·H William Kelly
Oct 18, 2000·The Cochrane Database of Systematic Reviews·E H Walters, J Walters
Dec 9, 2008·Clinics in Laboratory Medicine·I-Wen Yu, Bonny Lewis Bukaveckas

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