Abstract
To discuss relevant aspects in a series of cases in which interferon-α-triggered depressive symptoms persisted up to 4 years after therapy cessation in HCV-infected patients. Two experienced psychiatrists (AGA and LCQ) identified these four cases in a systematic evaluation program of HCV patients in the Hepatology Unit of the Teaching Hospital at the Federal University of Bahia, Brazil. Lifetime psychiatric diagnoses were confirmed by the Mini International Neuropsychiatric Interview (MINI Plus), and a questionnaire was submitted in order to gather clinical and sociodemographic characteristics. In three out of the four cases identified, major depression diagnosis was reached after more than 12 months of interferon-α therapy interruption and, in one case, depression recurred 6 months after antiviral treatment cessation in a patient on antidepressants. The only case that referred a past history of psychiatric diagnosis reported no offer of mental health care despite the presence of a major depressive episode with psychotic features and suicidal behaviour during the cytokine usage. Interferon-α-triggered depression may remain undiagnosed even in tertiary university hospitals, may persist years after the antiviral therapy cessation...Continue Reading
References
Aug 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P Bedossa, T Poynard
Aug 10, 2001·Psychosomatics·K AdemmerJ Clemens
Apr 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lucile CapuronAndrew H Miller
Jul 23, 2003·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Bénédicte GohierJean-Bernard Garré
Oct 19, 2004·Journal of Affective Disorders·Jennifer M Loftis, Peter Hauser
Dec 4, 2004·Biological Psychiatry·Lucile Capuron, Andrew H Miller
Aug 13, 2005·International Clinical Psychopharmacology·Sanjeev Sockalingam, Ken Balderson
Apr 25, 2006·Journal of Clinical Gastroenterology·Gregory M Asnis, Richard De La Garza
Apr 11, 2007·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Lucas C QuarantiniRodrigo A Bressan
Apr 25, 2007·Alimentary Pharmacology & Therapeutics·C L RaisonA H Miller
May 25, 2007·Current Psychiatry Reports·Brian Keefe
Sep 12, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Lucas C QuarantiniAngela Miranda-Scippa
Jan 1, 2008·General Hospital Psychiatry·Susana Carolina Batista-NevesAngela Miranda-Scippa
Jul 2, 2009·Psychosomatics·Peter de JongeFriedrich Stiefel
Jul 7, 2009·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Susana Batista-NevesAngela Miranda-Scippa
Aug 21, 2009·Alimentary Pharmacology & Therapeutics·F SchmidtM Schaefer
Sep 16, 2009·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Sanjeev Sockalingam, Susan E Abbey
Dec 16, 2009·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Thomas WobrockPeter Falkai
Mar 25, 2010·Psychosomatics·Amira Pierucci-LaghaUNKNOWN HALT-C Trial Group
Citations
Apr 4, 2013·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Jennifer BrownGeorge Benson
Jan 28, 2014·General Hospital Psychiatry·Amanda Galvão-de AlmeidaCamila Guindalini
Jun 23, 2011·Brain, Behavior, and Immunity·Amanda Galvão-de AlmeidaCamila Guindalini
Sep 16, 2014·Journal of Psychosomatic Research·Marilyn HuckansJennifer M Loftis