Is the liver kinetic growth rate in ALPPS unprecedented when compared with PVE and living donor liver transplant? A multicentre analysis

HPB : the Official Journal of the International Hepato Pancreato Biliary Association
Kristopher P CroomeDavid M Nagorney

Abstract

The clinical perspective on hepatic growth is limited. The goal of the present study was to compare hepatic hypertrophy and the kinetic growth rate(KGR) in patients after the ALPPS (Associating Liver Partition with Portal Vein Ligation for Staged Hepatectomy) procedure, portal vein embolization (PVE) and living donor liver transplantation. Volumetry and KGR of the future liver remnant (FLR) were compared from (15) patients undergoing ALPPS, (53) patients undergoing PVE, (90) recipients of living donor liver grafts and (93) donors of living donor liver grafts. The degree of hypertrophy was significantly greater after ALPPS (84.3 ± 7.8%) than after PVE (36.0 ± 27.2%) (P < 0.001). The KGR was also significantly greater for ALPPS [32.7 ± 13.6 cubic centimetres (cc)/day] (10.8 ± 4.5%/day) compared with PVE (4.4 ± 3.2 cc/day) (0.98 ± 0.75%/day) (P < 0.001). The FLR of living donor donors had the greatest degree of hypertrophy (107.5 ± 39.2%) and was greater than after ALPPS (P = 0.02), PVE (P < 0.001) and in living donor-recipient grafts (P < 0.001). KGR (cc/day) was greater in FLR of living donor donors compared with both ALPPS (P < 0.001) and PVE (P < 0.001). The KGR in patients undergoing ALPPS and living donor liver transplantati...Continue Reading

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Citations

Sep 9, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Raphael P H MeierPietro E Majno
Aug 4, 2015·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Kristopher P CroomeDavid M Nagorney
May 5, 2016·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kristopher P CroomeUNKNOWN Mayo Clinic Collaborative in Transplant Research and Outcomes
Aug 16, 2016·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Patryk KambakambaMickael Lesurtel
Nov 12, 2016·World Journal of Surgery·Kerollos Nashat WanisRoberto Hernandez-Alejandro
Mar 9, 2017·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Andras BudaiAttila Szijarto
May 23, 2017·World Journal of Radiology·Janio SzklarukMichelle Underwood
May 3, 2018·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Ernesto SparrelidBengt Isaksson
Nov 30, 2019·Journal of Gastroenterology and Hepatology·Ji-Hua Shi, Pål-Dag Line
Mar 31, 2016·World Journal of Hepatology·Taku Aoki, Keiichi Kubota
Aug 9, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Yutaro KikuchiKuniya Tanaka
Sep 27, 2018·Updates in Surgery·Giovanni VennarecciGiuseppe Maria Ettorre
Jun 26, 2020·World Journal of Surgical Oncology·Jan BednarschUlf Peter Neumann
Sep 2, 2021·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Javier Maupoey IbáñezRafael López-Andújar

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