Is the mammosomatotrope a transitional cell for the functional interconversion of growth hormone- and prolactin-secreting cells? Suggestive evidence from virgin, gestating, and lactating rats

Endocrinology
T E PorterL S Frawley

Abstract

Serum concentrations of PRL and GH increase and decrease, respectively, during the progression from nonpregnancy through lactation. However, it is unknown whether the secretory capacities and/or relative abundance of cells that release PRL or GH are altered during these physiological states. In the present study anterior pituitaries from adult virgin, gestating, and early or late lactating female rats were dispersed with trypsin and subsequently assayed for PRL and GH release using reverse hemolytic plaque assays. We found that the relative abundance of PRL-secreting cells was greater and that of GH cells lower in pituitaries from lactating females than in those from virgins. Moreover, the relative amounts of both PRL and GH released per cell were diminished in gestating and lactating females. For PRL, this decrease could be accounted for by an increase in the number of cells that released small quantities of hormone. We then performed simultaneous plaque assays to determine whether the shifts in the relative proportions of PRL and GH secretors were due to changes in the percentages of cells that secrete each hormone alone or in the fraction that releases both PRL and GH concurrently. Variations in both single and dual hormone-...Continue Reading

Citations

Dec 16, 1997·Journal of Cellular Physiology·P R Spangler, B C Delidow
Mar 1, 1992·Molecular and Cellular Endocrinology·T E PorterL S Frawley
Sep 1, 1992·Molecular and Cellular Endocrinology·R J Mogg, F R Boockfor
May 1, 1996·Domestic Animal Endocrinology·J A Proudman, B C Wentworth
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·C MissaleP Spano
Jan 11, 1992·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·L StefaneanuL Jin
Apr 6, 2002·Archives of Physiology and Biochemistry·E SeuntjensC Denef
Dec 30, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Verónica Filippa, Fabian Mohamed
Aug 21, 2007·Biochemical and Biophysical Research Communications·Nam Oak LeeByung Ju Lee
Sep 18, 2012·Frontiers in Neuroendocrinology·P R Le TissierP Mollard
Sep 22, 2016·Molecular and Cellular Endocrinology·Leonard Y M CheungMaría Inés Pérez-Millán
Jan 13, 2017·The American Journal of Surgical Pathology·M Beatriz S LopesJulie Polder
Feb 24, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·S VidalH S Smyth
Mar 7, 2003·American Journal of Physiology. Cell Physiology·Antonny CzarneckiLaurence Bresson-Bepoldin
Mar 1, 1997·The American Journal of Physiology·J P CastañoL S Frawley
Nov 18, 2000·American Journal of Physiology. Cell Physiology·A CzarneckiL Bresson-Bepoldin

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