PMID: 11163153Feb 13, 2001

Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

Current Opinion in Genetics & Development
K Labib, J F Diffley

Abstract

The MCM2-7 complex is essential for both the initiation and elongation phases of eukaryotic chromosome replication. There is some evidence that MCM2-7 proteins may act as a DNA helicase; at the same time, a variety of other DNA helicases have also been implicated in the replication of eukaryotic chromosomes.

References

Jan 1, 1992·Annual Review of Biochemistry·E Fanning, R Knippers
Dec 1, 1990·Genes & Development·K M HennessyD Botstein
Jan 1, 1989·Annual Review of Biochemistry·M D Challberg, T J Kelly
Nov 10, 1995·The Journal of Biological Chemistry·M E BuddJ L Campbell
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·M E Budd, J L Campbell
Jun 1, 1995·The Journal of Cell Biology·I T TodorovStephen E Kearsey
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·P RomanowskiR A Laskey
Jan 7, 1997·Proceedings of the National Academy of Sciences of the United States of America·R S WilliamsBruce Stillman
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·G W BrownT J Kelly
Sep 26, 1997·The Journal of Biological Chemistry·Y Ishimi
Mar 14, 1998·Molecular Biology of the Cell·A Lopez-GironaP Russell
May 9, 1998·The Journal of Biological Chemistry·Y IshimiH Kimura
Aug 5, 1998·Biochimica Et Biophysica Acta·Stephen E Kearsey, K Labib
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·W JiangT Hunter
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·Zvi KelmanJ Hurwitz
Jan 25, 2000·The Journal of Biological Chemistry·Tatyana A Prokhorova, J Julian Blow
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·J P ChongBruce Stillman
May 10, 2000·Current Opinion in Cell Biology·D G Lee, Stephen P Bell
May 24, 2000·Proceedings of the National Academy of Sciences of the United States of America·J K KarowI D Hickson
Jun 29, 2000·Annual Review of Biochemistry·Bik K Tye
Jul 13, 2000·The Journal of Cell Biology·R D Vale
Jul 25, 2000·Nucleic Acids Research·K H LeeY S Seo

Citations

Apr 21, 2005·Seminars in Cell & Developmental Biology·Christin Cvetic, Johannes C Walter
Feb 19, 2002·Trends in Cell Biology·J Julian Blow, Ben Hodgson
Aug 30, 2008·Nature Reviews. Cancer·J Julian Blow, Peter J Gillespie
Sep 25, 2003·Nature Reviews. Molecular Cell Biology·Arne Stenlund
Oct 24, 2002·European Journal of Biochemistry·Linda HollandKrassimir Yankulov
Jul 17, 2009·The Journal of Biological Chemistry·Shlomo EisenbergBik-Kwoon Tye
Feb 2, 2011·The Journal of Biological Chemistry·Agnieszka GambusJ Julian Blow
Feb 21, 2002·Molecular Biology of the Cell·Karola LindnerStephen E Kearsey
May 15, 2002·Molecular Biology of the Cell·Reiko Nakajima, Hisao Masukata
Jul 4, 2001·The EMBO Journal·J Julian Blow
Jul 24, 2002·Nucleic Acids Research·Heike Uhlmann-SchifflerHans Stahl
Mar 11, 2003·Nucleic Acids Research·Dávid SzütsTorsten Krude
Jun 12, 2003·Nucleic Acids Research·R N de JongP C van der Vliet
Aug 9, 2003·Nucleic Acids Research·Ian GraingeDale B Wigley
Apr 30, 2005·Nucleic Acids Research·Conrad A NieduszynskiAnne D Donaldson
Jan 30, 2007·Nucleic Acids Research·Elizabeth R BarryStephen D Bell
Apr 7, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anne EarlyJ F Diffley
Aug 5, 2004·European Journal of Biochemistry·Georgia XouriStavros Taraviras
Jun 5, 2002·Annual Review of Biochemistry·Stephen P Bell, Anindya Dutta
Jul 17, 2007·Annual Review of Genetics·Robert A Sclafani, T M Holzen
May 29, 2010·Mediators of Inflammation·Joseph Fomusi Ndisang
May 3, 2014·Archaea : an International Microbiological Journal·Felipe SarmientoWilliam B Whitman
Jul 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·David Shechter, Jean Gautier
Nov 12, 2014·Molecular Biology International·Mitali DasGopeshwar Narayan
Apr 28, 2004·Current Opinion in Genetics & Development·Julie M Bailis, Susan L Forsburg
Apr 21, 2004·The Journal of Cell Biology·Maren OehlmannJ Julian Blow
Nov 20, 2002·The Journal of Cell Biology·Ruth A Van HattenW Matthew Michael
Mar 14, 2007·Trends in Microbiology·Richard T Pomerantz, Mike O'Donnell
Aug 27, 2004·The EMBO Journal·Marcin Pacek, Johannes C Walter
Jan 22, 2005·Cellular Microbiology·Suchismita DasAnuradha Lohia
Oct 13, 2011·The Journal of Pathology·Gareth Williams, Kai Stoeber
Mar 19, 2003·Archives of Oral Biology·Jirina BartkovaJiri Bartek
Feb 24, 2005·DNA Repair·Shay Ben Aroya, Martin Kupiec
Aug 11, 2006·Experimental Cell Research·Mandana Namdar, Stephen E Kearsey
Feb 24, 2006·Journal of Molecular Biology·Victoria L MarshStephen D Bell
Jul 9, 2005·Trends in Biochemical Sciences·Tatsuro S TakahashiJohannes C Walter
Jul 15, 2011·Enzyme Research·Simone Guedes CalderanoMaria Carolina Elias
May 23, 2001·Current Biology : CB·J F Diffley
Aug 20, 2005·Molecular Cell·Vesna TodorovicMauro Giacca
Nov 26, 2003·Molecular Cell·Stephen E Kearsey, Sue Cotterill
Apr 30, 2003·Molecular Cell·Cyrus VaziriAnindya Dutta
Oct 21, 2004·Molecular Cell·Robin M Ricke, Anja-Katrin Bielinsky
Apr 7, 2012·Journal of Oncology·Charlotte A BrownDouglas P Malinowski
Jun 17, 2004·British Journal of Cancer·S B WhartonG H Williams
Apr 20, 2005·Oncogene·David Y Takeda, Anindya Dutta
Feb 12, 2002·Nature Cell Biology·Seiji Tanaka, J F Diffley
Jan 28, 2003·Nature Structural Biology·Ryan J FletcherXiaojiang S Chen
Sep 27, 2005·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Thomas D FriedrichJohn M Lehman
Feb 17, 2006·The EMBO Journal·Hideo NishitaniTakeharu Nishimoto
Jan 25, 2007·The Journal of Biological Chemistry·Yuling ShiRandal S Tibbetts
Jun 28, 2002·The Journal of Biological Chemistry·Melissa C EdwardsJohannes C Walter
Jul 17, 2001·The Journal of Biological Chemistry·Y Ishimi, Y Komamura-Kohno
Aug 23, 2002·The Journal of Biological Chemistry·Ken-ichiro YanagiFumio Hanaoka
Aug 25, 2004·The Journal of Biological Chemistry·David ShechterJean Gautier
Feb 1, 2005·The Journal of Pathology·Ellen C ObermannKai Stoeber
Sep 25, 2001·The Journal of Biological Chemistry·Y IshimiH Masai
May 13, 2003·The Journal of Biological Chemistry·Turid EidePhilippe Collas
Oct 14, 2005·The Journal of Biological Chemistry·Ryan J FletcherXiaojiang S Chen

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