Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?
The MCM2-7 complex is essential for both the initiation and elongation phases of eukaryotic chromosome replication. There is some evidence that MCM2-7 proteins may act as a DNA helicase; at the same time, a variety of other DNA helicases have also been implicated in the replication of eukaryotic chromosomes.
Identification of nuclear pre-replication centers poised for DNA synthesis in Xenopus egg extracts: immunolocalization study of replication protein A
Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe
A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication
XMCM7, a novel member of the Xenopus MCM family, interacts with XMCM3 and colocalizes with it throughout replication
Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase
Dna2 of Saccharomyces cerevisiae possesses a single-stranded DNA-specific endonuclease activity that is able to act on double-stranded DNA in the presence of ATP
The single minichromosome maintenance protein of Methanobacterium thermoautotrophicum DeltaH contains DNA helicase activity
Identification of the Xenopus laevis homolog of Saccharomyces cerevisiae DNA2 and its role in DNA replication
Sequential MCM/P1 subcomplex assembly is required to form a heterohexamer with replication licensing activity
The Saccharomyces Pif1p DNA helicase and the highly related Rrm3p have opposite effects on replication fork progression in ribosomal DNA
The cyclin-dependent kinase Cdc28p regulates distinct modes of Cdc6p proteolysis during the budding yeast cell cycle
The intrinsic DNA helicase activity of Methanobacterium thermoautotrophicum delta H minichromosome maintenance protein
The nuclease activity of the yeast DNA2 protein, which is related to the RecB-like nucleases, is essential in vivo
Isolation and characterization of various complexes of the minichromosome maintenance proteins of Schizosaccharomyces pombe
Saccharomyces cerevisiae CSM1 gene encoding a protein influencing chromosome segregation in meiosis I interacts with elements of the DNA replication complex
Identification of a second proliferating cell nuclear antigen in the human malarial pathogen Plasmodium falciparum
Distinct parts of minichromosome maintenance protein 2 associate with histone H3/H4 and RNA polymerase II holoenzyme
SpSld3 is required for loading and maintenance of SpCdc45 on chromatin in DNA replication in fission yeast
Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death
The requirement of yeast replication origins for pre-replication complex proteins is modulated by transcription
Radiation-induced double-strand breaks require ATM but not Artemis for homologous recombination during S-phase
Mechanisms involved in regulating DNA replication origins during the cell cycle and in response to DNA damage
Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress
The fertilization-induced DNA replication factor MCM6 of maize shuttles between cytoplasm and nucleus, and is essential for plant growth and development
Cdt1 and geminin are down-regulated upon cell cycle exit and are over-expressed in cancer-derived cell lines
Human cytomegalovirus infection leads to accumulation of geminin and inhibition of the licensing of cellular DNA replication
Role of DNA replication proteins in double-strand break-induced recombination in Saccharomyces cerevisiae
Nuclear distribution and chromatin association of DNA polymerase alpha-primase is affected by TEV protease cleavage of Cdc23 (Mcm10) in fission yeast
Novel role for checkpoint Rad53 protein kinase in the initiation of chromosomal DNA replication in Saccharomyces cerevisiae
Differential requirement of DNA replication factors for subtelomeric ARS consensus sequence protosilencers in Saccharomyces cerevisiae
Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress
Comparative analysis of the molecular mechanisms controlling the initiation of chromosomal DNA replication in yeast and in mammalian cells
Factors affecting germline mutations in a hypervariable microsatellite: a comparative analysis of six species of swallows (Aves: Hirundinidae)
Analysis of Mcm2-7 chromatin binding during anaphase and in the transition to quiescence in fission yeast
Minichromosome maintenance proteins 2 and 5 expression in muscle-invasive urothelial cancer: a multivariate survival study including proliferation markers and cell cycle regulators
Psoralen-sensitive mutant pso9-1 of Saccharomyces cerevisiae contains a mutant allele of the DNA damage checkpoint gene MEC3
CDK- and Cdc45-dependent priming of the MCM complex on chromatin during S-phase in Xenopus egg extracts: possible activation of MCM helicase by association with Cdc45
Cdc7-Dbf4 phosphorylates MCM proteins via a docking site-mediated mechanism to promote S phase progression
Xenopus Mcm10 binds to origins of DNA replication after Mcm2-7 and stimulates origin binding of Cdc45
Caspase-mediated cleavage of importin-alpha increases its affinity for MCM and downregulates DNA synthesis by interrupting the binding of MCM to chromatin
MCM8 is an MCM2-7-related protein that functions as a DNA helicase during replication elongation and not initiation
Role of protein biomarkers in the detection of high-grade disease in cervical cancer screening programs
Minichromosome maintenance proteins 2 and 5 in non-benign epithelial ovarian tumours: relationship with cell cycle regulators and prognostic implications
Distinct patterns of MCM protein binding in nuclei of S phase and rereplicating SV40-infected monkey kidney cells
Identification of carboxyl-terminal MCM3 phosphorylation sites using polyreactive phosphospecific antibodies
MCM2-7 complexes bind chromatin in a distributed pattern surrounding the origin recognition complex in Xenopus egg extracts
Physical and functional interaction between the mini-chromosome maintenance-like DNA helicase and the single-stranded DNA binding protein from the crenarchaeon Sulfolobus solfataricus
Phosphorylation of Mcm4 at specific sites by cyclin-dependent kinase leads to loss of Mcm4,6,7 helicase activity
Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity
Molecular mechanisms of eukaryotic origin initiation, replication fork progression, and chromatin maintenance
Proteolysis of DNA replication licensing factor Cdt1 in S-phase is performed independently of geminin through its N-terminal region
Evidence for a role of MCM (mini-chromosome maintenance)5 in transcriptional repression of sub-telomeric and Ty-proximal genes in Saccharomyces cerevisiae
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