PMID: 11163153Feb 13, 2001

Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

Current Opinion in Genetics & Development
K Labib, J F Diffley


The MCM2-7 complex is essential for both the initiation and elongation phases of eukaryotic chromosome replication. There is some evidence that MCM2-7 proteins may act as a DNA helicase; at the same time, a variety of other DNA helicases have also been implicated in the replication of eukaryotic chromosomes.


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