Is the mechanisms of fipronil-induced thyroid disruption specific of the rat: Re-evaluation of fipronil thyroid toxicity in sheep?

Toxicology Letters
Julien LeghaitCatherine Viguié

Abstract

In rat, fipronil treatment increases the elimination of thyroid hormones (TH). Relevance of this mechanism for the risk of fipronil for human health is subject to controversy because of the specificities of adult rat for TH plasma binding properties which often lead to the assumption that rats are more sensitive than human to thyroid disruption. This study aimed at determining if the mechanism of fipronil-induced thyroid disruption is altered in sheep a species more relevant to human from the standpoint of TH plasma binding. TSH, total triiodothyronine and free and total tetra-iodothyronine 24 h secretory profiles were not modified by fipronil treatment (5 mg/kg every 4 days per os) in rams. In euthyroid-like thyroidectomised ewes, the effect of this treatment was limited to a moderate increase in free T4 clearance. In contrast with the rat, fipronil treatment (0.5 mg/kg/day, IV for 14 days) had no effect on antipyrine clearance, a marker for hepatic cytochrome activity, in ewes. The differences between rat and sheep for the potential of fipronil as a thyroid disruptor might be related to the difference in the exposure to the toxicant, the actual exposure to the sulfone metabolite of fipronil being lower in sheep than in rat.

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Citations

Mar 27, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Béatrice B RoquesCatherine Viguié
May 28, 2011·Thyroid : Official Journal of the American Thyroid Association·Fabrice HerinJean-Marc Soulat
Sep 22, 2011·General and Comparative Endocrinology·Véronique GayrardPierre-Louis Toutain
Oct 9, 2015·Environmental Science & Technology·Ana Lopez-AntiaRafael Mateo
Jan 11, 2012·Environmental Pollution·Stéphane ReynaudMuriel Raveton
Sep 11, 2013·Chemosphere·J P CravediL Debrauwer
May 23, 2013·Polish Journal of Veterinary Sciences·Z Siroka, Z Svobodova
Jun 19, 2014·Environmental Science and Pollution Research International·David GibbonsPierre Mineau
Jul 15, 2018·Journal of Molecular Endocrinology·Karen J OliveiraTania Maria Ortiga-Carvalho
Dec 5, 2019·AAPS PharmSciTech·Gabriela Carmelinda Martins Dos SantosYara Peluso Cid
Sep 20, 2016·Critical Reviews in Toxicology·Xu WangZonghui Yuan
Mar 26, 2021·Journal of Veterinary Pharmacology and Therapeutics·Lucila CantonLaura Moreno

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