Is the nausea and vomiting of early pregnancy really feto-protective?

Journal of Perinatal Medicine
M Margaret WeigelMiriam Betancourt

Abstract

Health care providers and popular press articles frequently advise women that nausea and vomiting of early pregnancy (NVP) portends a favorable fetal outcome. To investigate the claim that NVP protects against adverse fetal outcomes and improves placental and fetal growth. Data were collected on a prospective cohort of 849 Ecuadorian prenatal patients beginning in early gestation until postpartum. A questionnaire collected information on NVP and other maternal characteristics. Fetal outcomes and placental characteristics were examined using anthropometry and physical examination. Multivariate statistical methods controlled for potential confounders. Women with nausea only (AOR = 0.45; 95% CI = 0.22-0.94) or nausea with vomiting (AOR = 0.66; 95% CI = 0.46-0.99) had significantly decreased miscarriage risk although the strength of the protection appeared less than that reported for other populations. NVP was not associated with low birth weight, preterm delivery, congenital anomaly, or other outcomes excepting slightly increased mean infant thigh skinfold (P = 0.024), mid-upper arm circumference (P = 0.049), and placental weight (P = 0.034). The data did not support the common belief that NVP protects against multiple adverse out...Continue Reading

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Citations

Jan 20, 2012·Journal of Immigrant and Minority Health·M Margaret Weigel, Maria Elena Caiza Sanchez
Dec 17, 2009·Maternal and Child Health Journal·Ronna L ChanSandra L Martin
Sep 6, 2011·Ecology of Food and Nutrition·M Margaret WeigelMonica Reyes
Sep 24, 2010·Human Reproduction·Ronna L ChanSandra L Martin
Dec 3, 2014·Physiology & Behavior·Agnieszka Żelaźniewicz, Bogusław Pawłowski
Sep 16, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gabor VermesNándor Ács
Apr 12, 2014·Journal of Theoretical Biology·Scott Forbes
Aug 14, 2012·Ecology of Food and Nutrition·Crystal L Patil
Aug 14, 2012·Ecology of Food and Nutrition·Crystal L PatilSera L Young
Sep 21, 2018·Frontiers in Pharmacology·Gareth J Sanger, Paul L R Andrews

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