Is the oral fungal pathogen Candida albicans a cariogen?

Oral Diseases
Dfa PereiraL P Samaranayake

Abstract

Pathobiology of dental caries is complex. Data from recent molecular microbiologic studies have further redefined the role of the oral microbiome in the etiology of dental caries. This new information challenges the conventional view on the hegemony of classic cariogenic prokaryotes such as Streptococcus mutans in caries etiology, and raises the intriguing possibility of the participation of the eukaryotic oral fungal pathogen Candida in the caries process. The virulence attributes of Candida species such as their acidogenicity and aciduric nature, the ability to develop profuse biofilms, ferment and assimilate dietary sugars, and produce collagenolytic proteinases are all indicative of their latent cariogenic potential. Based on the above, oral candidal counts have been used by some as a caries risk indicator. On the contrary, other studies suggest that Candida is merely a passenger extant in an acidic cariogenic milieu, and not a true pathogen. In this review, we critically examine the varying roles of Candida, and traditionally accepted cariogens such as the mutans group of streptococci in the pathobiology of dental caries. The weight of available data tends to imply that Candida may play a pivotal role as a secondary agent ...Continue Reading

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Citations

May 23, 2018·Oral Diseases·Herath Mudiyansalage Herath Nihal BandaraLakshman Perera Samaranayake
Jul 4, 2018·Oral Diseases·Kausar Sadia FakhruddinLakshman Perera Samaranayake
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Aug 29, 2019·Biofouling·Thamires Priscila CavazanaAlberto Carlos Botazzo Delbem
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Apr 21, 2020·Probiotics and Antimicrobial Proteins·Bhagavathi Sundaram SivamaruthiChaiyavat Chaiyasut
Jun 5, 2020·BMC Oral Health·Kausar Sadia FakhruddinLakshman Perera Samaranayake
Apr 9, 2019·International Journal of Dentistry·Charlene W J Africa, Mervyn Turton
Mar 5, 2020·Journal of Oral Microbiology·Kausar Sadia FakhruddinSiripen Pesee
Aug 27, 2018·Lasers in Medical Science·Kinga Grzech-LeśniakMarzena Dominiak
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Aug 23, 2020·Toxins·Amanda Pissinatti CanelliMaurício Ventura Mazzi
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Feb 26, 2021·Journal of Oral Microbiology·Hoa Thanh NguyenSusumu Kajiwara
Jul 2, 2021·International Journal of Antimicrobial Agents·Chengguang ZhuBiao Ren
Jul 3, 2021·Microorganisms·Xiuqin ChenDeog-Hwan Oh
Jul 23, 2021·PloS One·Alice AlbertiLakshman Perera Samaranayake
Sep 23, 2018·Journal of Endodontics·Giovanni MergoniMaddalena Manfredi
Sep 10, 2020·Archives of Oral Biology·Gustavo EidtRodrigo Alex Arthur

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